Pathogenesis of Leprosy and Related Diseases

Pathogenesis of Leprosy and Related Diseases provides insights into the pathology of granulomatous conditions. The book discusses topics on the factors that induce immunosuppression; immunohistological spectra of granulomatous diseases; study of cutaneous leishmaniasis; and the validity of histopathological analysis. Pathologists, immunologists, experimentalists, and researchers in the medical field will find the book interesting.

ContentsForeword Preface Abbreviations 1 Introduction The Study of PathogenesisThe Calibration of A Histopathological PicturePart I General Considerations2 The Structure of Skin The Skin BiopsyThe Normal Skin3 The Structure of Peripheral Nerve MicroanatomyResponse To Disease4 Inflammation Inflammatory CellsAcute and Chronic InflammationGranuloma FormationNecrosis and FibrosisImmune Complexes and Inflammation5 Concepts of the Spectrum Part II Leprosy6 The Leprosy Bacillus Growth CharacteristicsMorphology and Constitution7 The Disease Called LeprosyIntroductionThe Pathogenesis of the Clinical PictureImmunology8 The Early Skin Lesion of Leprosy The Evolution of the LesionProtected and Optimal SitesThe Portal of Entry9 Neuropathy in Leprosy The Pathway of Nerve InvolvementThe Neuropathology of LeprosyThe Pathogenesis of the LesionNeural Affinity, Immunological Protection and Autoimmunity10 Leprosy As A Systemic Disease Respiratory TractVascular DiseaseReticuloendothelial SystemOther Organs and Tissues11 Nature of the Leprosy Spectrum Basis of the Ridley-Jopling ClassificationImmunopathology of the SpectrumEvolution of the Response12 Activity of the Infection Phases of Bacterial MultiplicationThe Macrophage CycleViable and Dead BacilliReactivity and Relapse13 Reactions Type 1 (Borderline) ReactionsErythema Nodosum LeprosumExacerbation Reactions14 The Defect in Leprosy Epidemiological ConsiderationsGenetic InheritancePortal of EntryThe Evolution of the ResponseImmunosuppression15 Histological Diagnosis Principles of DiagnosisEarly LesionsTuberculoid LesionsDifferentiation of Reaction and Relapse16 Classification Histological Classification in SkinHistological Classification in NervePart III Related Diseases17 Leishmania and Leishmaniasis Speciation and Form of DiseaseThe Spectrum of Cutaneous Leishmaniasis18 Leishmaniasis: The Tissue Response Onset of InfectionGeneral Pathology of Cutaneous LeishmaniasisAlternative Modes of EvolutionMucocutaneous LeishmaniasisVisceral Leishmaniasis19 Leishmaniasis: Pathogenesis Initiation of the InfectionMechanisms of Parasite EliminationImmunosuppression20 Tuberculosis and Its Pathology The Tubercle BacillusGeneral PathologyThe Spectrum of Tuberculosis21 Pathogenesis of Tuberculosis Mechanisms of NecrosisKilling Mechanisms22 Some Other Granulomas Other Mycobacterial GranulomasGranulomas of Unknown AetiologyGranulomas Due To Known MoleculesModes of Cell Death23 Determinants of the Course of Infection Appendix: Technical Methods Fixation of TissuesStaining of Organisms in SectionsIdentification of Antigen in TissuesIndex

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