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It's the year 2030 in the post-apocalyptic city known as ROTVILLE, where people infected by a plague disease are quarantined. The director of Colosseo Super Max Prison, a penitentiary located inside the quarantined city, has carried out hundreds of inhumane experiments on inmates in an effort to make an enhanced human. He selects twenty-year-old Dylan, a psychologically disturbed inmate to be his prototype super soldier. He is confident he can transform the weak Dylan into a military killing machine through genetic engineering, and control him via a controversial memory-implant program. The director plans to showcase the obedient and super-enhanced Dylan in a gladiator tournament to his investors, who will then beg him to purchase similar soldiers.
But the plan goes awry when a group of rabid human mutants, the result of a top-secret project gone wrong, break out of Colosseo and flee into the nearby city. In the ensuing panic, the neuro-technician in charge of implanting Dylan's memories makes a last-minute decision and changes course. She inserts her own memory program instead, one that teaches independence rather than obedience, and trains Dylan to be a modern-day samurai. And now the super-warrior Dylan must break out of Colosseo, save the neuro-technician's son inside the quarantined city, and somehow keep himself and the child from being torn to shreds by bloodthirsty mutants, while also avoiding being recaptured and returned to his prison hell to be paraded in the gladiator tournament for the director and investors' entertainment.