Clinical Tumor Immunology

Clinical Tumor Immunology contains the proceedings of the Symposium of Clinical Tumor Immunology held in Brussels, Belgium, on May 26-29, 1975) and organized by the European Organization for Research on Treatment of Cancer in cooperation with the Department of Immunology of the University Hospital of Brussels. The papers explore progress in the field of clinical tumor immunology and cover topics ranging from general mechanisms in tumor immunity to tumor antigens and immunotherapy. A classification of leukemias and lymphomas is also presented. Comprised of 48 chapters, this book begins with an overview of the biological activities of the circulating thymic hormone, followed by a discussion on macrophage secretions affecting the growth of other cells. The reader is then introduced to immune cellular mechanisms at the site of the tumor; the use of the leukocyte migration technique in studies of tumor-directed cellular immunity in malignant melanoma; and immunological approaches to the identification of leukemic cells. Subsequent chapters deal with preclinical approaches in tumor immunochemotherapy; mediation of immune responses to human tumor antigens with "immune" RNA; and the role of transfer factor in human cancer. This monograph will be of interest to oncologists and immunologists.

Introduction The Immunological Dream of an Oncologist EORTC, Aim, Structure and ActivityGeneral Mechanisms in Tumor Immunity Biological Activities of the Circulating Thymic Hormone Macrophage Secretions Affecting the Growth of Other Cells Immune Cellular Mechanisms at the Site of the TumorTests in Cancer Patients T-Cell Rosettes in Human Cancer Cell-Mediated Cytotoxicity in Vitro. Mechanisms and Relevance to Tumor Immunity Function and Evaluation of Human K-Cells Lymphocyte Stimulation Test for Detection of Tumor Specific Reactivity in Humans The Leucocyte Migration Technique in Studies of Tumor-Directed Cellular Immunity in Malignant Melanoma Detection of Cell-Mediated Immunity Against Tumor-Associated Antigens of Human Breast Carcinoma by Migration Inhibition and Lymphocyte-Stimulation AssaysTumor Antigens The Use of CEA (Carcinoembryonic Antigen) and Other Carcinofoetal Antigens Human CancerHL-A in Cancer HL-A and CancerClassification of Leukemias and Lymphomas Immunological Approaches to the Identification of Leukaemic Cells Lymphocyte Membrane Markers in B-cell Proliferations and Human Non-Hodgkin's Lymphomas Classification of Leukemias and Hematosarcomas Based on Cell Membrane Markers and Scanning Electron MicroscopyImmunotherapy Preclinical Approaches in Tumor Immunochemotherapy Levamisole in Resectable Human Bronchogenic Carcinoma Mediation of Immune Responses to Human Tumor Antigens with "Immune" RNA Transfer Factor: The Current Picture, with Special Reference to Human Cancer New Frontiers of Cancer Active Immunotherapy The Immunotherapy of Acute Myeloblasts Leukaemia Immunotherapy of Human Solid Tumors: Prolongation of Disease-free Interval and Survival in Malignant Melanoma, Breast and Colorectal CancerAbstracts of Papers Presented at the SymposiumAuthor IndexSubject Index