Hepatic De Novo Lipogenesis and Regulation of Metabolism

The liver is the largest solid vital organ in mammals that supports other organ in the body in some facet.  This book synthesizes all the primary and relevant metabolic information that one needs to review to understand the complex and diverse role of the liver in metabolism. With the current epidemic of metabolic diseases, it is of immediate importance to understand the contribution of the liver in health and its role in the development of impaired metabolic regulation. This book covers the many studies that have unmasked important roles that proteins expressed in the liver play in the development of or protection from metabolic diseases. One of the major metabolic functions of the liver is to carry out de novo lipogenesis, which is the metabolic pathway that allows the conversion of excess carbohydrates into fatty acids. The process of de novo lipogenesis is covered in depth within this volume.  The book is an important contribution to the vast literature and ongoing research on liver function.

James M. Ntambi, PhD, is the Katherine Berns Von Donk Steenbock Professor in Nutrition, Department of Chemistry, College of Agricultural and Life Sciences, at the University of Wisconsin, Madison.

Transcriptional Regulation of De Novo Lipogenesis in Liver.- The Molecular Basis of Hepatic De Novo Lipogenesis in Insulin Resistance.- Regulation of Hepatic Metabolism by the Mechanistic Target of Rapamycin.- FoxO1: A Conductor of Insulin Signaling to Glucose and Lipid Metabolism.- Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease.- Role of the Endocannabinoid System in Hepatic Lipogenesis.- Role of Lipogenesis and Lipid Desaturases in Non-Alcoholic Fatty Liver Disease.- Lipid Droplet Proteins and Lipid Metabolism.- Influence of Gut Microbiota on Hepatic Lipogenesis and Disease Pathogenesis.- Hepatic Lipogenesis: Nutritional Control and Pathophysiological Relevance.- Metabolic Rhythm of Hepatic Lipogenesis: Regulation and Roles in Metabolism.- Monounsaturated Fatty Acid Mediated Liver-adipose Tissue Crosstalk and Metabolic Regulation.- Adipose Tissue DNL and Its Role in Metabolic Homeostasis.- The Lipogenic Effect of Insulin Revisited.- Index.