High-Risk Cutaneous Squamous Cell Carcinoma

This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.-

Chrysalyne Schmults, MD, MSCE Director, Mohs & Dermatologic Surgery Center Brigham & Women's Hospital Department of Dermatology 1153 Centre St., Suite 4349 Jamaica Plain, MA 02130, USA

1. Introduction.- 2. DEFINING THE PROBLEM OF HIGH-RISK SCC: Epidemiology and Outcomes of SCC/Scope of The Problem.- 3. The Evidence For Clinical and Histologic Risk Predictors.- 4. Tumor Staging Systems and Prognostic Stratification.- 5. THE SCIENCE OF SCC: Molecular/Genetic Underpinnings of Tumorormation/Progression/Metastasis/Immunosurveillance.- 6. MANAGEMENT: Management of Patients With Multiple Sccs/Field Cancerization.- 7. Management of High-Risk Primary Tumors.- 8. Management of Extensive Local Recurrence/In-Transit Metastasis.- 9. Management of Nodal Metastases.- 10. Management of Widely Metastatic and Unresectable Disease.