Hypothalamic Hormones

Hypothalamic Hormones is a collection of papers that elucidates the various aspects, chemical properties, effects, and history of hypothalamic hormones. The book is composed of five chapters on the detailed study of hypothalamic hormones. Chapter 1 is about a review of basic and clinical studies of corticotropin releasing factor (CRF); thyrotropin releasing hormone (TRH); prolactin releasing factor; prolactin-release inhibiting factor; factors affecting the release of melanotropin; luteinizing hormone release hormone (LHRH); growth hormone release factor; and somatostatin. The second chapter is a discussion on the various aspects of luteinizing hormone release hormone (LHRH). Subsequent chapters are concerned with the study of factors that control the secretion of growth hormone, with particular emphasis on brain neurotransmitters; the mechanism of action of hypothalamic hormones; and effects of androgens, estrogens, and other peripheral hormones on the hypothalamus function. The last chapter gives a history of neurosecretion and neuroendocrinology. Biochemists, physicians, pharmacologists, endocrinologists, researchers, and students in the medical field will find this book invaluable.

List of ContributorsPrefaceContents of Previous Volumes1. Hypothalamic Peptide Hormones: Basic and Clinical Studies I. Introduction II. Corticotropin-Releasing Factor (CRF) III. Thyrotropin-Releasing Hormone (TRH) IV. Prolactin-Releasing Factor (PRF) V. Prolactin-Release-Inhibiting Factor (PIF) VI. Factors Affecting the Release of Melanocyte-Stimulating Hormone (MSH) VII. The LH- and FSH-Releasing Hormone (LH-RH/FSH-RH) VIII. Growth Hormone-Releasing Factor (GH-RF) IX. Growth Hormone Release-Inhibiting Hormone (GH-RIH, Somatostatin) References2. Gonadoliberin I. Introduction II. Extraction and Purification of Gonadoliberin from Different Sources III. Determination of the Primary Structure of Gonadoliberin IV. Conformational Studies on Gonadoliberin V. Chemical Syntheses of Gonadoliberin VI. Structure-Activity Relationship for Gonadoliberin VII. Gonadoliberin Biosynthesis and Biodegradation VIII. Control of Gonadoliberin Release IX. Biological Effects of Gonadoliberin X. Bioassay for Gonadoliberin XI. Immunological Studies with Gonadoliberin XII. Cellular Mechanism of Action of Gonadoliberin XIII. Agonist and Antagonist Analogues of Gonadoliberin XIV. Concluding Remarks References3. The Control of Somatotropin Secretion I. Introduction II. Secretion Pattern of GH in Different Animal Species III. Stimuli for GH Secretion IV. Central Nervous System Control of GH Secretion V. Feedback Control of GH Secretion VI. Concluding Remarks References4. Mechanisms of Action of Hypothalamic and Peripheral Hormones in the Anterior Pituitary Gland I. Introduction II. Role of Cyclic AMP in the Action of TRH, LH-RH, and Somatostatin III. Role of Prostaglandins in Hypothalamic Hormone Action on Adenohypophysis IV. Adenohypophyseal Cyclic AMP-Dependent Protein Kinase and Its Substrates V. Interactions between LH-RH, Sex Steroids, and Inhibin in the Control of LH and FSH Secretion VI. Antagonism between Estrogens and Thyroid Hormone in the Control of TSH Secretion: Role of TRH Receptors VII. The Pituitary Dopamine Receptor: Potent Antidopaminergic Activity of Estrogens on Prolactin Secretion References5. Neurosecretion and Neuroendocrinology in Historical Perspective I. Introduction II. Discovery of Neurosecretory Neurons III. One-Step Neurohormonal Activities IV. Neuroendocrine Axis V. Nonneurohormonal Functions of Peptidergic Neurons VI. Biochemistry of Neurosecretory Products VII. Developmental Relationships and the APUD Concept VIII. Conclusions ReferencesAuthor IndexSubject Index