Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells

Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.

Selected topics: Pulmonary bronchiolar epithelial cytotoxicity: microanatomical considerations, C. G. Plopper. Xenobiotic metabolism by isolated pulmonary bronchiolar and alveolar cells, T. R. Devereux et al. Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung, J. Baron & J. M. Voigt. Purification and characterization of lung enzymes involved in xenobiotic metabolism, F. P. Guengerich. Action by the lungs on circulating xenobiotic agents, with a case study of physiologically based pharmacokinetic modeling of benzo(a)pyrene disposition, R. A. Roth & A. Vinegar. Metabolism of endogenous and xenobiotic substances by pulmonary vascular endothelial cells, U. S. Ryan & A. P. Li. Naphthalene and 2-methylnaphthalene-induced pulmonary bronchiolar epithelial cell necrosis: metabolism and relationship to toxicity, R. B. Franklin et al. Pulmonary toxicity of 4-ipomeanol, T. E. Gram. Pulmonary toxicity induced by phosphorothioate impurities present in organophosphate insecticides, J. Gandy et al. The metabolic basis of 3-methylindole-induced pneumotoxicity, T. M. Bray & J. B. Kirkland. Metabolism and pulmonary toxicity of butylated hydroxytoluene, H. Witschi et al. Hepatic nonaltruism and pulmonary toxicity of pyrrolizidine alkaloids, R. J. Huxtable. Cyclophosphamide: pulmonary metabolism, toxicity and protective effect of vitamin E, J. M. Patel. Metabolic activation and biological effects of nitrosamines in the mammalian lung, H. M. Schüller et al. The use of bleomycin in model systems to study the pathogenesis of interstitial pulmonary fibrosis, J. S. Lazo et al. The pulmonary toxicity of nitrosoureas, A. C. Smith. Index.