T Cell Activation by CD1 and Lipid Antigens

Molecular Biology.- Evolutionary Biology of CD1.- Architecture of CD1 Proteins.- Structure and Biology of Self Lipid Antigens.- Structures and Functions of Microbial Lipid Antigens Presented by CD1.- Cellular Biology.- CD1 Expression on Antigen-Presenting Cells.- Pathways of CD1 and Lipid Antigen Delivery, Trafficking, Processing, Loading, and Presentation.- TCR-Mediated Recognition of Glycolipid CD1 Complexes.- Development and Selection of V?14i NKT Cells.- Disease.- CD1-Restricted T Cells in Host Defense to Infectious Diseases.- NKT Cells and Autoimmune Diseases: Unraveling the Complexity.- iNKT Cells in Allergic Disease.- CD1-Restricted T Cells and Tumor Immunity.- Harnessing NKT Cells for Therapeutic Applications.

Section 1 - Molecular Biology.- Chapter 1 - Evolutionary Biology of the CD1.- Chapter 2 - Architecture of CD1 Proteins.- Chapter 3 - Structures and Biology of Self Lipid Antigens.- Chapter 4 - Structures and Functions of Microbial Lipid Antigens.- Section 2 - Cellular Biology.- Chapter 5 - CD1 Expression on Antigen Presenting Cells.- Chapter 6 - Pathways of CD1 and Lipid Antigen Delivery, Trafficking, Processing, Loading and Presentation.- Chapter 7 - TCR-Mediated Recognition of Glycolipid CD1 Complexes.- Chapter 8 - Development and Selection of Va14i NKT Cells.- Section 3 - Disease.- Chapter 9 - CD1-Restricted T Cells in Host Defense to Infectious Diseases.- Chapter 10 - NKT Cells and Autoimmune Diseases: Unraveling the Complexity.- Chapter 11 - iNKT Cells in Allergic Disease.- Chapter 12 - CD1-Restricted T Cells and Tumor Immunity.- Chapter 13 - Harnessing NKT Cells for Therapeutic Applications.- Subject index