Transition Metal Toxicity

International Review of Experimental Pathology, Volume 31: Transition Metal Toxicity merges discussions of normal and deranged metabolism of transition metals; redox cycling of metal ions in biological systems; oxidative stress during the metabolic interactions of metal ions; and the actions of oxygen-derived free radicals in the pathogenesis of metal ion toxicity. The book also describes the roles played by chromium and other metals in carcinogenesis; the morphologic pathology of metal toxicosis; and metal ion overload due to inborn metabolic defects, as well as to excessive environmental exposure. Research findings at the molecular, cellular, and organ levels are reviewed. Physiologists, biochemists, pathologists, and biophysicists will find the book invaluable.

Contributors PrefaceIron Toxicosis I. Introduction: History and Prevalence of Iron Toxicosis II. Chemistry of Iron Toxicity III. Pathophysiology of Iron Overload IV. Treatment of Iron Overload References Host Defenses against Copper Toxicity I. Essentiality of Copper in Normal Metabolism II. Balance between Essential Copper Levels and Toxicosis III. Regulation of Copper Balance: Control of Homeostasis in Animals IV. Copper Homeostasis in Nonanimal Cells V. Conclusions References Chromium Toxicity and Carcinogenesis I. Introduction II. Uptake-Reduction Model of Chromium(VI) in the Cell III. Chromium(VI)-Induced DNA Damage IV. Conclusion References The Chemistry of Dioxygen Species (O2, O2-, HOO·, and HOOH) and Their Activation by Transition Metals I. Introduction II. Redox Chemistry of O2, O2-, and HOOH III. Reactivity of O2- and HOO· IV. Iron-Induced Activation of HOOH V. Iron-Induced Activation of Dioxygen References Transition Metal Ions and Oxygen Radicals I. Introduction II. The Chemistry of Oxygen Species III. The Biochemistry and Biology of Oxygen Species IV. Mechanism of the Toxicity of Oxygen Radicals V. The Dual Effect of Transition Metal Ions VI. Defenses against Oxygen Species Derived Damage References The Cytopathology of Metal Overload I. Introduction II. Iron III. Copper References Index