Viral Immunology and Immunopathology

Viral Immunology and Immunopathalogy covers topics concerning the role of cellular and humoral immunity in viral infections, factors responsible for the persistence and recurrence of viral infections in the presence of immunity, mechanisms of viral immunopathology, and concepts in the development of vaccines. The book describes the history of viral immunology; the synthesis and properties of viral antigens; and the humoral immune response to viruses. The text also discusses the mechanisms of viral neutralization; cellular immunity; the role of inflammatory cells and effector molecules in combating viral infections; and the genetic control of resistance. The book concludes with chapters on herd immunity; viral immunopathology; and viral immunology and immunopathology. Immunologists, pathologists, virologists, and microbiologists will find the book useful.

ContentsAuthors and ParticipantsPreface1. History of Viral Immunology2. Viral Replication3. Viral Antigens4. Humoral Immune Response to Viral Infections5. Mechanisms of Viral Neutralization6. Destruction of Virus-Infected Cells by Antibody and Complement7. Cell-Mediated Immunity in Viral Infections8. The Role of the Inflammatory Response in Viral Infections9. Interferon as a Mediator of Cellular Immunity in Viral Infections10. Genetic Control of Resistance to Viral Infection in Mice11. Persistence of Viral Infection in the Presence of Immunity 12. Radioimmunoassays for Detection of Viral Antigens and Antiviral Antibody 13. Immune Response to Hepatitis Viruses 14. Immune Response to Leukemia Viruses in Mice 15. Immune Responses to Epstein-Barr Virus 16. Herd Immunity-Changing Concepts 17. Current Approaches to Viral Immunoprophylaxis 18. Subunit Viral Vaccines 19. Adverse Effects of Viral Vaccines20. Immune-Complex Disease Associated with Viral Infections 21. Virus-Induced Cell-Mediated Immunopathological Disease 22. The Effect of Viral Infections on the Function of the Immune System 23. Autoimmunity in Viral Infections 24. The Future in Viral Immunology and Immunopathology Appendix. Summary of Workshop Subject Index