Aptasensors for Point-of-Care Diagnostics

The design and fabrication of aptamer-based biosensors for point-of-care testing of disease diagnostic and prognostic is an upthrust and interdisciplinary area of research. This book covers the design and development of novel cost-effective aptamer-based biosensors for disease diagnostic and prognostic including an understanding of health care management in terms of timely updates of disease situations in a particular geographical area. It also discusses the scaling up and market trend of aptamer-based devices for extension of research from lab to market, and end users. Features: - Explains the design and fabrication of aptasensors-based diagnostic devices - Includes novel approaches and comprehensive technology overview for diagnosis management towards early-stage detection of various biomarkers associated with several health conditions - Demonstrates possible benefits of combined diagnostics and therapeutic possibilities using aptamer-based point-of-care technologies devices - Discusses emerging implications and recent advances of biosensing platforms for designing and developing aptamer-based point-of-care testing (POCT) devices - Explores aptamer-based approach to develop advanced platforms for medical applications and open arena for state-of-the-art future research This book is aimed at researchers and graduate students in biomedical engineering, diagnostics, nanobiotechnology, and materials science.

Arpana Parihar is currently working as a Women Scientist B at CSIR- AMPRI, Bhopal, MP, India, under the scheme of DST-WoS-B awarded from the Department of Science and Technology, Government of India. Raju Khan is currently working as a Principal Scientist and Associate Professor at CSIR-AMPRI Bhopal, Madhya Pradesh, India. He has more than 15 years of experience in electrochemistry, and development of biosensors-based diagnostics.

1. Overview of aptamer-based biosensors 2. Biomarkers for aptamer-based diagnostic applications 3. Designing and synthesis of aptamer via various approaches (SELEX and ExSELEX) 4. A comparative study of aptasensor versus immunosensor for biomarker detection 5. Aptamer-based point-of-care diagnostic devices for infectious diseases 6. Aptamer-based colorimetric biosensor 7. Aptamer beacon probes for the detection and visualization of miRNA 8. Microfluidics-enabled aptamer-based sensing devices - the aptafluidics microdevices 9. Fabrication of aptamer-based electrochemical biosensor for health care monitoring 10. Challenges and advances in aptamer-based biosensing approaches 11. Current perspectives of aptasensors as diagnostic tools for oncological diseases