Biochemical Actions of Hormones V6

Biochemical Actions of Hormones, Volume VI is a 10-chapter text that summarizes the regulation of protein kinases and phosphoprotein phosphatases and the relationship of the endocrines to cancer. This volume describes first the precise structures of steroid hormones and carcinogens. The subsequent chapters cover the hormonal regulation of chemical carcinogenesis; the importance of steroid hormones as growth factors for mammary tumors; the effects of steroid hormones in the central nervous system; and the properties of the purified estrogen receptor. A chapter highlights the biochemical actions of neurohypophysial hormones and neurophysin. Another chapter presents the biochemistry and physiology of cytokinin, a plant hormone. The final chapter exemplifies the multihormonal systems by control of the a2u-globulin produced in the liver. This book will be of great value to endocrinologists.

List of ContributorsPrefaceContents of Previous Volumes1. The Physiological Regulation and Function of cAMP-Dependent Protein Kinases I. Introduction II. Properties of the cAMP-Dependent Protein Kinase III. Approaches for Evaluating the Function of cAMP-Dependent Protein Kinase: In Vitro and In Vivo Criteria IV. Specific Systems Addendum References2. Hormonal and Metabolic Control of Phosphoprotein Phosphatase I. Introduction II. Enzyme Properties III. Hormonal Control IV. Conclusions References3. Structural Aspects of Steroid Hormones and Carcinogenic Polycyclic Aromatic Hydrocarbons I. Structures of Steroids II. Biochemical Mechanisms Involving Steroids That Have Been Studied by Crystallographic Techniques III. Carcinogenic Polycyclic Aromatic Hydrocarbons and Their Structural Similarities to Steroids IV. Summary Appendix References4. Modulation of Chemical Carcinogenesis by Hormones I. Introduction II. Mammary Gland III. Ovary IV. Liver V. Relationship of Binding Proteins (Enzymes) and Carcinogenesis VI. Conclusions Addendum References5. How Important Are Steroids in Regulating the Growth of Mammary Tumors? I. General Comments on Mammary Tumor Growth II. Growth Characteristics of Human Breast Tumors III. Regulation of Cell Proliferation IV. Cell Loss V. Blood Supply VI. Cell-Cell Interaction VII. Immune Response to Breast Tumors VIII. Conclusions References6. Biochemical Actions of Neurohypophysial Hormones and Neurophysin I. Introduction: Physiological Actions of Neurohypophysial Hormones II. Neurophysins III. Neurohypophysial Hormone-Receptor Interactions IV. Neurohypophysial Hormone Stimulus Generation V. Relationship between Stimulus Generation and Response VI. Molecular Events Mediating Neurohypophysial Hormone Action VII. Concluding Comments References7. Biochemistry and Physiology of Cytokinins I. Introduction II. Effects of Physiological Processes III. Chemistry and Structure-Activity Relationships IV. Metabolism of Cytokinins V. Cytokinins in Nucleic Acids VI. Effects of Cytokinins on Metabolism VII. Concluding Remarks References8. Steroid Hormone Receptors in the Central Nervous System I. Introduction II. Technical Aspects of Measuring Steroid Binding to Putative Receptors in Brain and Pituitary III. Neural and Pituitary Steroid Receptors in Relation to Function IV. Concluding Remarks References9. Properties of Estrogen Receptor Purified to Homogeneity I. Introduction II. Purification to Homogeneity Estrogen Receptor III. Properties of Estrogen Receptor Purified to Homogeneity IV. Final Remarks and Conclusions References10. Hormonal Regulation of a2u Globulin in Rat Liver I. Introduction II. Androgen-Dependent Synthesis of a2u Globulin and Its Modulation by Other Hormonal and Developmental Factors III. Cytoplasmic Androgen Binding Protein of Rat Liver and Its Possible Role in the Regulation of a2u Globulin IV. Messenger RNA for a2u Globulin and Its Regulation by Various Hormones V. Concluding Remarks ReferencesIndex