Biochemical Actions of Hormones V8

Biochemical Actions of Hormones, Volume VIII is an eight-chapter text that covers the developments in the understanding of the biochemical aspects of hormonal action and regulation. This volume examines first the messenger functions of calcium in hormonal systems. The next chapters deal with the neuronal regulation of blood pressure; the regulation of protein synthesis by phosphorylation; and the hormonal control of hepatic gluconeogenesis. These topics are followed by discussions on the effects of insulin in intracellular functions, the mechanisms of steroidal hormones, and the membrane recognition and effector sites in steroid hormone action. A chapter focuses on the activation of steroid-receptor complexes. The final chapters survey the estradiol and progesterone receptors in the human endometrium. This book will be of great value to biologists, biochemists, and researchers in the field of hormonal action.

List of ContributorsPreface1. The Messenger Function of Calcium in Endocrine Systems I. Introduction II. Historical Perspective III. Cellular Calcium Metabolism IV. Stimulus-Response Coupling V. Interrelationships between Calcium and Cyclic Nucleotides in Stimulus-Response Coupling VI. Calcium as Messenger in Specific Systems VII. Conclusions References2. Neuronal Regulation of Blood Pressure I. Organization of Central Nervous System Areas Regulating Blood Pressure II. Peripheral Regulation III. Central Nervous System Regulation IV. Conclusion References3. Regulation of Protein Synthesis by Prosphorylation I. Introduction II. Ribosomes III. Initiation Factors IV. Hemin Regulation of Protein Synthesis V. Interferon and Double-Stranded RNA Activated Inhibition of Protein Synthesis VI. Aminoacyl-tRNA Synthetases VII. Conclusions References4. Hormonal Control of Hepatic Gluconeogenesis I. Introduction II. Role of Cyclic AMP in Hormonal Control of Gluconeogenesis III. Sites of Action of Hormones on Hepatic Gluconeogenesis IV. Summary V. Overview References5. Effects of Insulin on Intracellular Functions I. Introduction II. Intracellular Effects of Insulin III. Mechanism of Insulin Action IV. Cellular Binding Sites for Insulin V. The Entry of Insulin into Target Cells VI. Hypothesis, Speculation, and Conclusion References6. Membrane Recognition and Effector Sites in Steroid Hormone Action I. Introduction II. Compartmentation in the Cellular Economy III. Cell Surface Specialization and the Occurrence of Recognition Systems IV. The Cell Surface: Alterations of Membrane Architecture on Binding Site Occupancy V. Dynamics of Cell Surface Recognition Sites: Molecular and Cellular Aspects VI. Evaluation of Current Models of Steroid Hormone Accumulation and Distribution in Target Cells VII. Closing Comments References7. Activation of Steroid-Receptor Complexes I. Introduction II. Methods of Studying Activation III. The Mechanism of Activation IV. Factors Effecting the Activation Reaction V. Reversal from the Activated to the Nonactivated State (Deactivation) VI. Use of Activation to Purify the Receptor VII. Conclusions References8. Estradiol and Progesterone Receptors in Human Endometrium I. Introduction II. Methodological Problems III. Estradiol and Progesterone Receptors in the Normal Menstrual Cycle IV. General Conclusions ReferencesIndexContents of Previous Volumes