Biosensors

Over the past 20 years, the field of biosensor research have had a significant impact in both laboratory research and the commercial sector. Over that period, biosensors have revolutionised the care and management of diabetes and have had important impacts in several other areas of clinical diagnostics. Europe, North America and Asia-Pacific have all seen the rise of small and medium sized companies seeking technical and application niches in the manufacture or use of biosensors. The current activity in both gene and protein 'biochips' can be seen as the latest set of tools that allow users who are not analytical science practitioners to make technically complex and reliable measurements with the minimum of intervention. Similarly the concern about the dissemination of chemical or biological weapons and the need for their rapid and reliable detection will need to be met by devices that have many characteristics in common with biosensors.
This book provides a practical introduction to the many skills needed in the highly interdisciplinary field of biosensor technology. Edited by two internationally renowned experts in this field it draws together contributions from active researchers in Europe, North America and Asia who describe how to implement techniques as diverse as protein engineering, optical and electrochemical instrumentation, single cell electrophysiology, screen printing and numerical modelling in the context of producing biosensors for both laboratory and commercial applications. As well as the many detailed protocols and experimental tips, the book also offers an overview of current research in this area as well as pointers to its further directions. The diversity of topics covered means that it will be suitable both for those already active in the area who wish to expand their repertoire of experimental tools and for those who are just starting out in biosensors research.

Professor JM Cooper FRSEProfessor of Bioelectronics, University of GlasgowDepartment of ElectronicsRankine BuildingUniversity Of GlasgowGlasgow, G12 8LT0141330493101413306010jmcooper@elec.gla.ac.ukFellow of the Royal Society of Edinburgh, Visiting Professor Tokyo Institute of Technology, Editor of "Nanobiotechnology"member of the Editorial Boards of "Biosensors and Bioelectronics" and Chemical Communications
Professor AEG Cass FRSCProfessor of Chemical Biology, Imperial College LondonDepartment of Biological SciencesBiochemistry BuildingImperial College LondonSouth Kensington CampusLondonSW7 2AZ0207594519502072250960t.cass@imperial.ac.ukFellow of the Royal Society of Chemistry, Awarded the Mullard Medal of the Royal Society, Visiting Professor Chinese Academy of Sciences, member of the Editorial Boards of "Biosensors and Bioelectronics" and "Nanobiotechnology"

- Preface - 1: Heller: Redox Hydrogel based Electrochemical Biosensors - 2: Caruana: Hybridization at Oligonucleotide sensitive electrodes - 3: Zhang: Screen printing methods for biosensor production - 4: Bartlett: Kinetic Modelling for Biosensors - 5: Coulet and Blum: Bio- Chemi- and Electrochemi- luminescence for fibre optic Biosensors - 6: Thompson et al: Determination of metal ions by fluorescence aniostropy - 7: Walt et al: Fluorescence-based fiber optic biosensors - 8: Vogel et al: Functional analysis of ion channels: Planar patch clamp and impedance spectroscopy of tethered lipid membranes - 9: Gilardi: Protein engineering for Biosensors