Capillary Electrophoresis in Biotechnology and Environmental Analysis

This text aims to evaluate the actual impact of high-performance capillary electrophoresis on analytical biotechnology and environmental analysis. The first part of the book presents a survey of present innovations in instrument design and different methods of pre-concentration techniques in order to obtain increased separations at higher sensitivities. The second part contains articles on applications of HPCE to protein and peptide analysis. In the third part, applications of HPCE in the investigation of drug abuse and drug interactions are presented. The last two parts of the book deal with the use of HPCE at low-UV wavelengths and negative-UV absorption. The book should be of interest to those working in HPCE research and applications.

Hasan Parvez (Edited by), P. Caudy (Edited by), P. Roland-Gosselin (Edited by)

Part 1 Technological innovations: capillary electrophoresis/mass spectrometry for the determination of bioactive proteins and peptides, K.B. Tomer et al; pre-concentration techniques in high-performance capillary electrophoresis, P. Roland-Gosselin et al; capillary electrophoresis with laser-induced fluorescence detection - optical design and applications, G. Nouadje, et al. Part 2 HPCE in protein and peptide analysis: analysis of protein folding by capillary electrophoresis, M.A. Strege et al; application of HPCE analysis to process monitoring in biotechnology, R. Freitag; isoform characterization, peptide mapping and amino-acid analysis of monoclonal antibodies by high-performance capillary electrophoresis, J.F. Veillon et al; capillary-zone electrophoresis and isotachophoresis of biologically-active peptides, V. Kasicka and Z. Prusik. Part 3 HPCE in drug abuse and drug interactions: analysis of drugs of abuse by micellar electrokinetic capillary chromatography, V.C. Trenerry and R.J. Wells; study of protein-drug binding by capillary-zone electrophoresis - prospects and problems, J.C. Kraak et al; HPCE of catecholamines, bioactive molecules and other transmitters, T. Kaneta and S. Tanaka; capillary-gel electrophoresis and antisense therapeutics - the analysis of DNA analogs, L.A. DeDionisio and D.H. Lloyd. Part 4 HPCE of carbohydrates, chiral and enantiomers: capillary electrophoresis of heparin-derived carbohydrate chains, J.B.L. Damm; chiral separation by HPCE with oligosaccharides - application to acidic compounds, A. D'Hulst and N. Verbeke; separation of enantiomers in capillary electrophoresis, T. Schmitt. Part 5 HPCE of anions and cations: negative absorbance - application to the detection of inorganic anions and cations in high-performance capillary electrophoresis, P. Roland-Gosselin et al.