Colloid and Interface Science in Pharmaceutical Research and Development

Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs.

Hiroyuki Ohshima is a Professor of Pharmaceutical Sciences at the Tokyo University of Science, Japan. He is the author or co-author of 10 books and over 300 book chapters and journal publications reflecting his research interests in colloid and interface sciences as well as biophysical chemistry. He spent his post-doc life at University of Melbourne, State University of New York at Buffalo, and University of Utah. Dr. Ohshima received the B.S. (1968), M.S. (1970), and Ph.D. (1974) degrees in physics from the University of Tokyo, Japan. Currently he edits two journals, Colloids and Surfaces B: Biointerfaces (Elsevier) and Colloid and Polymer Science (Springer). Kimiko Makino is a Professor of Pharmaceutical Sciences at the Tokyo University of Science, Japan. She is the author or co-author of 1 book and over 120 book chapters and journal publications reflecting her research interests in colloid and interface sciences as well as pharmaceutical science. She spent her post-doc life at University of Utah. Dr. Makino received the B.S. (1979), M.S. (1981), and Ph.D. (1986) degrees in pharmaceutical science from Tokyo University of Science. She currently serves as the head of the Center for Physical Pharmaceutics of Tokyo University of Science. She has just been appointed as new Co-Editor in Chief of Journal of Microencapsulation (Informa Healthcare/Taylor & Francis).

Part I Fundamentals Interaction between drugs Pharmaceutical suspensions Response of colloidal drugs to external fields Aggregation of drugs Concentrated drug particles Rheology of colloidal suspensions Part II Applications of Colloid and Interface Science in Pharmaceutical sciences Liposomes and micelles Binding of drugs on liposomes Drug delivery system Gold nanoparticles Drug permeation through biological membranes EPR effects Part III Measurements Zeta potential of colloidal drugs Atomic force microscope Surface force apparatus