Controlled Release Veterinary Drug Delivery

Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months). The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field. Controlled Release Veterinary Drug Delivery comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems. The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

Preface (M.J. Rathbone). Forward (K. Ellis). Utilization of biopharmaceutical and pharmacokinetic principles in the development of veterinary controlled release drug delivery systems (P. Inskeep). Mechanisms of drug release from controlled release veterinary drug delivery systems (M.J. Rathbone). Intraruminal controlled release products (J. Cardinal). Design parameters for post-ruminal drug delivery systems and rumen-stable products (S. Wu). Design and development of controlled release ocular veterinary drug delivery systems (R. Gurny). Design and development of controlled release intravaginal veterinary drug delivery systems (M.J. Rathbone). Controlled release drug delivery systems for estrous control of domesticated livestock (M.J. Rathbone). Controlled release products for control of ectoparacites of livestock (A.M. Knipling-Bushland). Controlled release products for companion animals (L. Witchey-Lakshmanan). Controlled release vaccines (T. Bowersack). In vitro drug release testing of controlled release veterinary drug products (M.J. Rathbone). Stability testing of veterinary drug products (M.J. Rathbone). USA regulatory aspects pertaining to controlled release veterinary drug delivery systems (D. Lindsey).