Cardiology Science and Technology

This book deals with the bioengineering models of heart function, with applications in cardiology and cardiac surgery. It consists of two sections. The first covers left ventricular (LV) wall stress, cardiac contractility, ventricular remodeling, active wall stress and systolic pressure generation, and vector cardiogram characteristics, with applications in cardiology. The second covers ECG signal analysis for arrhythmias detection, LV pumping (intra-LV, aortic, and coronary flow) characteristics, and coronary bypass design, with applications in cardiology and cardiac surgery. This book is like an exciting train ride through the heart and into blood flows within its chamber, the coronary tree, the aorta, and finally into the coronary bypass grafting. This fascinating journey helps us to fully appreciate cardiology from the STEM viewpoint. This book can be deemed to represent computational cardiology, and hence belongs to the emerging field of computational medicine.

Dhanjoo N. Ghista, PhD, University 2020 Foundation, Massachusetts, USA

LEFT VENTRICULAR WALL STRESS, CARDIAC CONTRACTILITY, CARDIOMYOPATHIC HEART REMODELING, ACTIVE WALL STRESS AND SYSTOLIC PRESSURE GENERATION, VECTOR CARDIOGRAM CHARACTERISTICS, WITH APPLICATIONS IN CARDIOLOGY: Left Ventricular Wall Stress Compendium. Cardiac Function Assessment in Filling and Systolic Phases: Passive and Active Elastances of the Left Ventricle. Novel Cardiac Contractility Index and Ventricular-Arterial Matching Index to Serve as Markers of Heart Failure. Cardiomyopathy Effect on Left Ventricular Function and Contractility and Improvement after Surgical Ventricular Restoration. Cardiac Contractility Measures for Left Ventricular Functional Assessment in Normal and Diseased Hearts. Analysis for Left Ventricular Pressure Increase during LV Isovolumic Contraction Phase due to Active Stresses in the Myocardial Fibers. Myocardial Infarct-Induced Left Ventricular Shape Remodeling and its Surgical Ventricular Restoration. Vector Cardiogram Theory and Clinical Application. ECG SIGNAL ANALYSIS AND LEFT VENTRICULAR PUMPING (INTRA-VENTRICULAR, AORTIC AND CORONARY FLOW) CHARACTERISTICS, CORONARY BYPASS SURGERY DESIGN, WITH APPLICATIONS IN CARDIOLOGY AND CARDIAC SURGERY: ECG Waveform Analysis and Heart Rate Variability Signal Analysis to Detect Cardiac Arrhythmias. Left Ventricular Blood Pump Analysis and Outcome: Intra-LV Flow and Pressure Distributions before and after Nitroglycerin Administration, to Determine Cardiac Contractility Outcome and Candidacy for Coronary Bypass Surgery. Cardiac Perfusion Analysis and Quantification: Cardiac Perfusion by Nuclear Cardiac Imaging and Computation of Intra-Myocardial Blood Flow Velocity and Pressure Patterns. Determination of Arterial Pulse Wave Propagation Velocity and Arterial Properties. Simulation of Blood Flow in Idealized and Patient-Specific Coronary Arteries with Curvatures, Stenoses, Dilatations, and Side-Branches. Intra-Left Ventricular Diastolic and Systolic Flow Velocity Distributions, Based on Color Doppler Echo Vector Flow Mapping of Normal Subjects and Heart Failure Patients. Coronary Blood Flow Analysis and Coronary Bypass Graft Flow and Design of Coupled Sequential Anastomotic Bypass Graftng.