High-Risk Cutaneous Squamous Cell Carcinoma

This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.-

Chrysalyne Schmults, MD, MSCE
Director, Mohs & Dermatologic Surgery Center
Brigham & Women's Hospital
Department of Dermatology
1153 Centre St., Suite 4349
Jamaica Plain, MA 02130, USA

Table of Contents
 
High-Risk Cutaneous Squamous Cell Carcinoma: A Practical Guide for Patient Management
 
 
 
Chrysalyne D. Schmults, editor
 
 
Dedication
Preface
 
 
 
Part I. Defining the Problem of High-risk SCC
 
Epidemiology and Outcomes of Cutaneous Squamous Cell Carcinoma Pritesh S. Karia
 
Tumor Staging Systems and Prognostic Stratification Anokhi Jambusaria-Pahlajani
 
Part II. The Science of SCC
 
Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-risk Cutaneous Squamous Cell Carcinoma Catherine Anne Harwood, Charlotte Proby, Sarah Arron
 
Molecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications Valerie Yanofsky, John A. Carucci, Günther F.L. Hofbauer
 
Part III. Management of High-risk SCC
 
Management of Patients with Multiple SCCs/Field Cancerization Sasha Jenkins Haberle, Lauren Rimoin, Myrto Georgia Trakatelli, Fiona Zwald
 
Management of High-Risk Primary Tumors including Nodal Staging Vishal Anil Patel, Christian L. Baum, Désirée Ratner
 
Management of Local Recurrence and In-transit Metastasis Vitaly Terushkin, John A. Carucci
 
Management of Nodal Metastases Michael Veness, Julie Howle
 
Management of Widely Metastatic and Unresectable Cutaneous Squamous Cell Carcinoma Glenn J. Hanna, Emily Stamell Ruiz, Jochen H. Lorch
 
Immune Dysfunction and Immunosuppression: Impacts on SCC Incidence, Prognosis, and Management Travis W. Blalock, Thomas Stasko