Microfluidic Devices for Biomedical Applications

Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.- Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications- Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies- Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

Contributor contact detailsWoodhead Publishing Series in BiomaterialsAbout the editorsPrefacePart I: Fundamentals of microfluidic technologies for biomedical applicationsChapter 1: Materials and methods for the microfabrication of microfluidic biomedical devicesAbstract:1.1 Introduction1.2 Microfabrication methods1.3 Materials for biomedical devices1.4 Polymers1.5 Conclusion and future trends1.7 Appendix: acronymsChapter 2: Surface coatings for microfluidic-based biomedical devicesAbstract:2.1 Introduction2.2 Covalent immobilization strategies: polymer devices2.3 Covalent immobilization strategies: glass devices2.4 Adsorption strategies2.5 Other strategies utilizing surface treatments2.6 Examples of applications2.7 Conclusion and future trends2.8 Sources of further information and adviceChapter 3: Actuation mechanisms for microfluidic biomedical devicesAbstract:3.1 Introduction3.2 Electrokinetics3.3 Acoustics3.4 Limitations and future trendsChapter 4: Digital microfluidics technologies for biomedical devicesAbstract:4.1 Introduction4.2 On-chip microdrop motion techniques4.3 Sensing techniques4.4 Future trends4.5 ConclusionPart II: Applications of microfluidic devices for drug delivery and discoveryChapter 5: Controlled drug delivery using microfluidic devicesAbstract:5.1 Introduction5.2 Microreservoir-based drug delivery systems5.3 Micro/nanofluidics-based drug delivery systems5.4 Conclusion5.5 Future trendsChapter 6: Microneedles for drug delivery and monitoringAbstract:6.1 Introduction6.2 Fabrication of microneedles (MNs)6.3 MN design parameters and structure6.4 Strategies for MN-based drug delivery6.5 MN-mediated monitoring using skin interstitial fluid (ISF) and blood samples6.6 Future trends6.7 ConclusionChapter 7: Microfluidic devices for drug discovery and analysisAbstract:7.1 Introduction7.2 Microfluidics for drug discovery7.3 Microfluidics for drug analysis and diagnostic applications7.4 Conclusion and future trends7.5 Sources of further information and advicePart III: Applications of microfluidic devices for cellular analysis and tissue engineeringChapter 8: Microfluidic devices for cell manipulationAbstract:8.1 Introduction8.2 Microenvironment on cell integrity8.3 Microscale fluid dynamics8.4 Manipulation technologies8.5 Manipulation of cancer cells in microfluidic systems8.6 Conclusion and future trends8.7 Sources of further information and adviceChapter 9: Microfluidic devices for single-cell trapping and automated micro-robotic injectionAbstract:9.1 Introduction9.2 Device design and microfabrication9.3 Experimental results and discussion9.4 Conclusion9.5 AcknowledgementsChapter 10: Microfluidic devices for developing tissue scaffoldsAbstract:10.1 Introduction10.2 Key issues and technical challenges for successful tissue engineering10.3 Microfluidic device platforms10.4 Conclusion and future trendsChapter 11: Microfluidic devices for stem cell analysisAbstract:11.1 Introduction11.2 Technologies used in stem cell analysis11.3 Examples of microfluidic platform for stem cell analysis: stem cell culture platform - mimicking in vivo culture conditions in vitro11.4 Examples of microfluidic platform for stem cell analysis: single stem cell analysis11.5 Microdevices for label-free and non-invasive monitoring of stem cell differentiation11.6 Microfluidics stem cell separation technology11.7 Conclusion and future trendsPart IV: Applications of microfluidic devices in diagnostic sensingChapter 12: Development of immunoassays for protein analysis on nanobioarray chipsAbstract:12.1 Introduction12.2 Technologies12.3 Immobilization chemistry12.4 Detection methods12.5 Applications12.6 Conclusion and future trendsChapter 13: Integrated microfluidic systems for genetic analysisAbstract:13.1 Introduction13.2 Integrated microfluidic systems13.3 Development of integrated microdevices13.