Motor System Disorders, Part I

Motor System Disorders: Normal Physiology and Function and Neuromuscular Disorders summarizes recent advances and best practice for understanding normal physiology and function of the larger motor system as well as the diagnosis, course, and treatment of neuromuscular disorders. The work will include neuroanatomy, circuits and synapses. It discusses how different parts of the brain contribute to motor control, including both vestibular and cerebellar motor control, as well as the influences of the parietal and frontal lobes. Diagnostic methods include genetic evaluation, electrodiagnosis, pathology, and brain imaging. Neuromuscular disorders of both children and adults will be included.- Identifies normal motor control physiology and function, including neuroanatomy, circuits, and synapses- Discusses vestibular and cerebral motor control and contributions of parietal and frontal lobes- Provides diagnostic methods, including genetic evaluation, electrodiagnosis, brain imaging, and pathology analyses- Summarizes the diagnosis, course, and best practice treatment of neuromuscular disorders- Explores neuromuscular disorders in adults and children

Section 1. Normal Physiology and Function1. Skeletal muscle structure, physiology, and function2. Upper and lower motor neuron neurophysiology and motor control3. Vestibular motor control4. Autonomic failure: Clinicopathologic, physiologic, and genetic aspects5. Gait control by the frontal lobe6. Parietal control of hand movement7. Immunology and microbiome: Implications for motor systems8. COVID-19 (novel SARS-CoV-2) neurological illnessSection 2. Clinical and Laboratory Diagnosis9. Neurogenetic motor disorders10. Neuromuscular electrodiagnosis11. Quantitative electrodiagnosis of the motor unit12. Neuromuscular pathology13. Electrophysiological assessment of peripheral and central autonomic disorders14. On the path to evidence-based therapy in neuromuscular disorders15. Advances in the neuroimaging of motor disorders16. Sleep-related motor disordersSection 3. Neuromuscular Disorders17. Neonatal and infantile hypotonia 18. Autoimmune inflammatory myopathies19. Childhood muscular dystrophies20. Distal myopathy21. Muscle channelopathies22. Congenital myopathies23. Mitochondrial encephalomyopathy24. Autoimmune polyneuropathies25. Hereditary neuropathy26. Acute/chronic inflammatory polyradiculoneuropathy27. Myasthenia gravis and congenital myasthenic syndromes28. Adult and childhood vasculitis29. Critical illness-associated weakness and related motor disorders

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