Semiconducting Silicon Nanowires for Biomedical Applications

Biomedical applications have benefited greatly from the increasing interest and research into semiconducting silicon nanowires. Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and applications of this emerging material.The book begins by reviewing the basics, as well as the growth, characterization, biocompatibility, and surface modification, of semiconducting silicon nanowires. It goes on to focus on silicon nanowires for tissue engineering and delivery applications, including cellular binding and internalization, orthopedic tissue scaffolds, mediated differentiation of stem cells, and silicon nanoneedles for drug delivery. Finally, it highlights the use of silicon nanowires for detection and sensing. These chapters explore the fabrication and use of semiconducting silicon nanowire arrays for high-throughput screening in the biosciences, neural cell pinning on surfaces, and probe-free platforms for biosensing.Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and tissue engineering, and researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive biomaterials.
- Reviews the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires
- Describes silicon nanowires for tissue engineering and delivery applications, including cellular binding and internalization, orthopedic tissue scaffolds, mediated differentiation of stem cells, and silicon nanoneedles for drug delivery
- Highlights the use of silicon nanowires for detection and sensing

Contributor contact detailsWoodhead Publishing Series in BiomaterialsForewordPart I: Introduction to silicon nanowires for biomedical applications1. Overview of semiconducting silicon nanowires for biomedical applicationsAbstract:1.1 Introduction1.2 Origins of silicon nanowires1.3 The structure of this book1.4 Conclusion1.5 References2. Growth and characterization of semiconducting silicon nanowires for biomedical applicationsAbstract:2.1 Introduction2.2 Synthesis methods for silicon nanowires (SiNWs)2.3 Characterization methods2.4 Synthesis of semiconductor SiNWs by the chemical vapor deposition (CVD) method2.5 Conclusion2.6 Future trends2.7 Sources of further information and advice2.8 References3. Surface modification of semiconducting silicon nanowires for biosensing applicationsAbstract:3.1 Introduction3.2 Methods for fabricating silicon nanowires (SiNWs)3.3 Chemical activation/passivation of SiNWs3.4 Modification of native oxide layer3.5 Modification of hydrogen-terminated silicon nanowires (H-SiNW)3.6 Site-specific immobilization strategy of biomolecules on SiNWs3.7 Control of non-specific interactions3.8 ConclusionReferences4. Biocompatibility of semiconducting silicon nanowiresAbstract:4.1 Introduction4.2 In vitro biocompatibility of silicon nanowires (SiNWs)4.3 In vivo biocompatibility of SiNWs4.4 Methodology issues4.5 Future trends4.6 Conclusion4.7 ReferencesPart II: Silicon nanowires for tissue engineering and delivery applications5. Functional semiconducting silicon nanowires for cellular binding and internalizationAbstract:5.1 Motivation: developing a nano-bio model system for rational design in nanomedicine5.2 Methods: non-linear optical characterization and surface functionalization of silicon nanowires (SiNWs)5.3 Applications: in vivo imaging and in vitro cellular interaction of functional SiNWs5.4 Conclusions and future trends5.5 References6. Functional semiconducting silicon nanowires and their composites as orthopedic tissue scaffoldsAbstract:6.1 Introduction6.2 Nanowire surface etching processes to induce biomineralization6.3 Nanowire surface functionalization strategies to induce biomineralization6.4 Construction of silicon nanowire (SiNW)-polymer scaffolds: mimicking trabecular bone6.5 The role of SiNW orientation in cellular attachment, proliferation and differentiation in the nanocomposite6.6 Conclusions and future trends6.7 Acknowledgement6.8 References7. Mediated differentiation of stem cells by engineered semiconducting silicon nanowiresAbstract:7.1 Introduction7.2 Methods for fabricating silicon nanowires (SiNWs)7.3 Regulated differentiation for human mesenchymal stem cells (hMSCs)7.4 SiNWs fabricated by the electroless metal deposition (EMD) method and their controllable spring constants7.5 Mediated differentiation of stem cells by engineered SiNWs7.6 Conclusion7.7 Future trends7.8 Acknowledgements7.9 References8. Silicon nanoneedles for drug deliveryAbstract:8.1 Introduction8.2 Strategies for nanoneedle fabrication8.3 Drug loading of nanoneedles and release patterns8.4 Drug delivery using nanoneedles8.5 Toxicity of nanoneedles8.6 Overview of nanoneedle applications8.7 Conclusion8.8 ReferencesPart III: Silicon nanowires for detection and sensing9. Semiconducting silicon nanowire array fabrication for high throughput screening in the biosciencesAbstract:9.1 Introduction9.2 Fabrication of silicon nanowire (SiNW) field effect transistor (FET) arrays for high throughput screening (HTS) in the biosciences9.3 Surface modification of SiNW FETs for HTS in the biosciences9.4 Integration of SiNW FETs with microfluidic devices for HTS in real-time measurements9.5 Examples/applications of SiNW FETs9.6 Conclusion9.7 Future trends9.8 References10. Neural cell pinning on surfaces by semiconducting silicon nanowire arraysAbstract:10.1 Introduction10.2 Toward control of neuronal topography and axo-dendritic polarity10.