Supercritical Fluid Chromatography and Extraction

Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Recent, significant improvements in instrumentation have rekindled interest in SFC and have enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its potential beyond traditional liquid chromatography, yet many of its capabilities remain underappreciated. Supercritical Fluid Chromatography and Extraction explores contemporary supercritical fluid chromatography and extraction and how it should be implemented in laboratory science for analysis, isolation, and production. New to This Edition This new edition details recent advances and applications of supercritical fluids in sample prep, instrumental analysis, and process-scale, including SFE, making it a comprehensive resource for both techniques. Further enhancements to this edition include:- Expanded section on SFC theory to include gradient elution- A new chapter on general detectors for SFC- Enhanced method development coverage, with focus on gradient elution practices- Includes multidimensional SFC, SFC × SFC, and LC-SFC- Features comprehensive information on accelerated solvents, comparing solvent and extraction techniques.- Highlights environmental monitoring and analysis applications of SFE.Widely used in the food industry for decades, SFE is now expanding into new fields. Supercritical Fluid Chromatography and Extraction, Second Edition serves as a valuable resource for chemical engineers, chemists, researchers, students, and academics working with supercritical fluids at preparative and process scales. It’s also an ideal introduction for newcomers to SFC and SFE.

1. Core concepts and milestones in the exploitation of supercritical fluids in separation science 2. Theory of supercritical fluid chromatography 3. Stationary phases for supercritical fluid chromatography 4. Stationary phases for the separation of stereoisomers by supercritical fluid chromatography 5. Co-solvents and mobile phase additives in supercritical fluid chromatography 6. Method development in supercritical fluid chromatography 7. Instrument platforms for supercritical fluid chromatography 8. General detectors for supercritical fluid chromatography 9. Mass spectrometric detection in supercritical fluid chromatography 10. Multidimensional supercritical fluid chromatography 11. Method validation in supercritical fluid chromatography 12. Sample preparation for supercritical fluid chromatography 13. Supercritical fluid chromatography of amino acids and peptides 14. Supercritical fluid chromatography of lipids 15. Supercritical fluid chromatography of stereoisomers 16. Applications of supercritical fluid chromatography in environmental analysis 17. Applications of supercritical fluid chromatography in food analysis 18. Applications of supercritical fluid chromatography in forensic analysis 19. Applications of supercritical fluid chromatography in natural product analysis 20. Applications of supercritical fluid chromatography in the analysis of petrochemicals 21. Applications of supercritical fluid chromatography in the pharmaceutical industry 22. Applications of supercritical fluid chromatography in bioanalysis 23. Theory for preparative supercritical fluid chromatography 24. Instrument platforms for preparative and process scale supercritical fluid chromatography 25. Applications of preparative and process scale supercritical fluid chromatography in the pharmaceutical industry 26. Applications of preparative and process scale supercritical fluid chromatography of natural products 27. Core concepts and fundamentals of supercritical fluid extraction 28. Instrument platforms for supercritical fluid extraction 29. Pressurized hot-water and accelerated solvent extraction 30. Supercritical fluid extraction of essential oils 31. Supercritical fluid extraction of lipids and bio-oils 32. Supercritical fluid extraction of agricultural products 33. Supercritical fluid extraction of petroleum products 34. Applications of Supercritical fluid extraction for environmental analysis