Stereo-Differentiating reactions

Stereo-Differentiating Reactions: The Nature of Asymmetric Reactions provides an introduction to asymmetric reactions. It brings together synthetic organic chemistry, stereochemistry, group theory, the theory of optical rotation, experimental methods, etc., all of which are basic to the study of stereo-differentiating reactions, to form a unified approach based on the new concept of "differentiation." The authors hope that the value of the new concept, which is rather more complex than conventional treatments of asymmetric reactions, will become clear in the present book. This new concept should be useful in many fields of study, not only the development of stereo-differentiating reactions, but also in the study of general reaction mechanisms in organic chemistry. The book contains nine chapters and begins with a historical background of studies on asymmetric reactions. This is followed by separate chapters on molecular symmetry and chirality; nomenclature for chirality, prochirality, and stereo-differentiating reactions; the mechanisms of stereo-differentiating reactions; methods for studying stereo-differentiating reactions; and the basic principle of optical activity.

PrefaceChapter 1 Historical BackgroundChapter 2 Molecular Symmetry and Chirality 2.1 Stereoisomerism 2.1.1 Classification According to Internal Energy 2.1.2 Classification According to Molecular Symmetry 2.2 Molecular Symmetry and Chirality 2.2.1 Method of Classification 2.2.2 Characteristics of Chiral Molecules and Counting Stereoisomers 2.2.3 Description of Isomers by Permutational Operations Appendix A Set and Group Appendix - Symmetry Permutational Groups Appendix C Polya's ProcedureChapter 3 Nomenclature for Chirality and Prochirality 3.1 Nomenclature for Chiral Molecules 3.1.1 Nomenclature for Using the R, S System 3.1.2 Nomenclature for Conformational Isomers 3.2 Prochirality 3.2.1 Enantiotopic Relationships 3.2.2 Diastereotopic Relationships 3.2.3 Nomenclature for ProchiralityChapter 4 Nomenclature for Stereo-Differentiating Reactions 4.1 Fundamentals 4.2 Definition of Stereo-Differentiating Reactions 4.2.1 Reaction Character and Stereo-Differentiation 4.2.2 Historical Definitions of Asymmetric Reactions 4.2.3 New Definition and Classification for Reactions of Related Asymmetric Reactions 4.3 General Discussion on Stereo-Differentiating Reactions 4.3.1 Enantio-Differentiating Reactions 4.3.2 Diastereo-Differentiating ReactionsChapter 5 Stereo-Differentiating Reactions 5.1 Enantio-Differentiating Reactions 5.1.1 Enantioface-Differentiating Reactions 5.1.2 Enantiotopos-Differentiating Reactions 5.1.3 Enantiomer-Differentiating Reactions 5.2 Diastereo-Differentiating Reactions 5.2.1 Factors Affecting the Efficiency of Diastereo-Differentiation 5.2.2 Diastereoface-Differentiating Reactions 5.2.3 Diastereotopos-Differentiating Reactions 5.2.4 Intramolecular Diastereoface- and Diastereotopos-Differentiating Reactions 5.3 Special Stereo-Differentiating ReactionsChapter 6 Miscellaneous Stereo-Differentiating Reactions Systems 6.1 Stereo-Differentiating Reactions in Polymerization 6.1.1 Relationships of Stereo-Differentiation and Stereoregulation in Polymer Synthesis 6.1.2 The Stereo-Differentiating Process in Polymerization 6.2 Stereo-Differentiation in Enzyme Reactions 6.2.1 Aconitase 6.2.2 Alcohol Dehydrogenase 6.2.3 Enantiomer-Differentiating Reactions 6.3 So-called Absolute Asymmetric Synthesis 6.3.1 Configurational Enantiomer-Differentiating Reactions 6.3.2 Conformational Enantiomer-Differentiating Reactions 6.3.3 Enantioface-Differentiating Reactions 6.4 Enantio-Differentiating RacemizationsChapter 7 Mechanisms of Stereo-Differentiating Reactions 7.1 The Kinetic Approach 7.2 The Use of Stereochemical Models 7.2.1 Empirical Stereochemical Models (Experimental Rules for Stereo-Differentiating Reactions) 7.2.2 Mathematical Formulation of Stereo-Differentiating Reactions 7.3 Illustration Based on the New Concept of "Differentiation"Chapter 8 Methods for the Study of Stereo-Differentiating Reactions 8.1 Requirements for Experimental Condition for Stereo-Differentiating Reactions 8.1.1 Substrate 8.1.2 Reagent and Catalyst 8.1.3 Reaction Conditions and Subsequent Isolation and Purification of the Reaction Products 8.1.4 Confirmation of the Experimental Accuracy 8.1.5 Confirmation of Stereo-Differentiation 8.2 Evaluation of Stereo-Differentiating Ability 8.2.1 Stereo-Differentiating Ability and the Degree of Differentiation 8.2.2 Terms Expressing the Proportion of Stereoisomers 8.2.3 Determination of the Proportion of Stereoisomers 8.2.4 Relationship Between the Ratio of Stereoisomers Produced and Degree of Stereo-Differentiation 8.2.