Tissue Engineering

Tissue engineering is an emerging interdisciplinary field, occupying a major position in the regenerative medicine that aims at restoring lost or damaged tissues and organs with use of cells. Regenerative medicine includes cellular therapy and tissue engineering. In general, the former treats patients by cell infusion alone, while tissue engineering needs biomaterials and growth factors in addition to cells. Biomaterials function in tissue engineering as the scaffold or template for cells to proliferate, differentiate, and produce matrices. Tissue Engineering focuses on the fundamentals (biomaterials, scaffolds, cell cultures, bioreactors, animal models etc.), recent animal and human trials, and future prospects regarding tissue engineering. Almost twenty years have passed since the advent of the tissue engineering, whicht uses cells, scaffolds, and growth factors for regeneration of neotissues. The number of investigations on tissue engineering is still increasing tremendously. Nevertheless, it seems likely that the number of reports describing clinical trials of tissue engineering will remain very limited. Even the studies that apply tissue engineering research to large animals have not been performed yet on a large scale. The major objective of this book is to address this question from a science and technology point of view, and to describe the principles of basic technologies that have currently been developed by numerous research groups.
- Helps reader understand the key issues required for promotion of clinical trials in tissue engineering
- Covers in full the issues related to tissue engineering
- Looking at current technologies in the field

Chapter 1: Scope of Tissue Engineering 1. Functions of Scaffold 2. Absorbable Biomaterials3. Pore Creation in Biomaterials 4. Special Scaffolds5. Surface Modifications 6. Cell Expansion and Differentiation 7. Growth Factors 8. Cell Sources Chapter 2: Animal and Human Trials of EngineeredTissues 1. Plastic Surgical System 2. Musculoskeletal System3. Cardiovascular and Thoracic System 4. Nervous System 5. Maxillofacial System 6. Gastrointestinal System 7. Urogenital System 8. Others Chapter 3: Basic Technologies Developed for Tissue Engineering 1. Biomaterials 2. Fabrication of Porous Scaffolds 3. Novel Scaffolds4. Surface Modification of Biomaterials and Cell Interactions 5. Growth Factors and Carriers6. Cell Culture7. Examples of Cell CultureChapter 4: Challenges in Tissue Engineering1. Problems in Tissue Engineering 2. Sites for Neotissue Creation3. Autologous or Allogeneic Cells 4. Cell Types5. Risks at Cell Culture6. Scaffolds for Large Animals and Human Trials7. Importance of Neovascularization 8. Carriers for Growth Factors 9. Primary Roles of Each Player in the Tissue Engineering Arena