Advances in Metabolic Disorders

Advances in Metabolic Disorders, Volume 4 covers the developments in the study of metabolic disorders. The book discusses the intestinal factors in the regulation of insulin secretion; antidiuretic hormone synthesis, release, and action under normal and pathological circumstances; and the symptoms, pathophysiology, diagnosis, and clinical syndromes of disaccharide malabsorption. The text also describes the hormonal control of fetal development and metabolism; the placental carbohydrate, fat, and protein metabolism; as well as the metabolic aspects of obesity. The use of liquid formula diets in metabolic studies is also considered. The book will prove invaluable to physicians, endocrinologists, physiologists, and medical students.

ContributorsPrefaceContents of Previous VolumesIntestinal Factors in the Regulation of Insulin Secretion I. Introduction II. Alimentary Augmentation of Insulin Secretion III. Morphological Considerations IV. Humoral Factors in the Control of Insulin Secretion; Intestinal Hormones V. Nonhumoral Factors in the Control of Insulin Secretion VI. Clinical Implications VII. Conclusions ReferencesAntidiuretic Hormone Synthesis, Release, and Action Under Normal and Pathological Circumstance I. Introduction II. Chemistry of Antidiuretic Hormone and Its Accompanying Substances in the Secreting Nerve Cells III. Chemical Synthesis of Vasopressin and Analogs IV. Synthetic Analogs as Substitutes or Blocking Substances for Antidiuretic Hormone V. Preparations of Labeled Vasopressin VI. Biosynthesis of Vasopressin VII. Determination VIII. Classification of the Vasopressin-Secreting Cells as Peptidergic Neurons IX. Can Release of Vasopressin Take Place Independently of Oxytocin Release? X. Recent Developments concerning Localization and Function of the Antidiuresis-lnducing Osmoreceptors XI. Effect of Nonosmotic Stimuli on the Function of the Vasopressinergic Cells XII. Mechanism of Release of Vasopressin from the Neurohypophysis XIII. Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) XIV. Diabetes Insipidus XV. Recent Developments concerning the Action of Vasopressin ReferencesDisaccharidase Deficiency I. Dietary Carbohydrates and Their Products II. Normal Disaccharide Absorption III. Disaccharide Malabsorption IV. Clinical Syndromes of Disaccharide Malabsorption ReferencesHormonal Control of Fetal Development and Metabolism I. Introduction II. Reckoning Fetal Stages III. Critical Stages and Permanent Effects in Testicular and Thyroid Physiology IV. The Anterior Pituitary in Fetal Development V. The Hormonal Control of Liver Glycogen VI. Fetal Lipids in Normal and Diabetic Pregnancies VII. Significance of Birth in Developmental Endocrinology ReferencesThe Metabolism of the Placenta I. Introduction II. Carbohydrate Metabolism III. Lipid Metabolism IV. Protein Metabolism V. Epilogue ReferencesMetabolic Aspects of Obesity I. Introduction II. Basic Physiology of Adipose Tissue III. Metabolic Abnormalities in Obesity ReferencesThe Use of Liquid Formula Diets in Metabolic Studies: 15 Years' Experience I. Introduction II. Advantages of Formula Feeding III. Patient's Acceptance of a Formula Regimen IV. Ingredients V. Formula Preparation, Storage, and Service VI. Fecal Excretion on a Formula Regimen VII. Applications in Animal Studies VIII. Human Energy Requirements, Judged by the Caloric Intake of 114 Adult Patients in the Metabolic Steady State ReferencesAuthor IndexSubject Index