Advances in Metabolic Disorders

Advances in Metabolic Disorders, Volume 3 is a compendium of papers that discusses the regulation of ketogenesis, spontaneous diabetes, ethanol-induced hypoglycemia, and hormonal syndromes associated with neoplasia. One paper discusses the primary role of long-chain fatty acids in synergistically controlling enhanced ketogenesis and gluconeogenesis found in the liver at the cellular level. Another paper notes that in rodent experiments, when hypertrophy and hyperplasia are maintained without exhaustion or degeneration and are sufficient in degree, a new equilibrium emerges leading to near-normalization or compensated diabetes. The opposite occurs when hypertrophy and hyperplasia are limited in degree or in duration: decompensation occurs, diabetes progresses. Some papers describe metabolic disorders of the ovary, erythropoietin, and thyroid diseases. One paper analyzes the pathological conditions arising from impairments of the hypothalamic-pituitary-ovarian-uterine axis that can cause disturbances in normal reproduction Another paper investigates if a competitive relationship exists between thyrotropin (TSH) and long-acting thyroid stimulator (LATS). In vivo and in vitro studies show that the effect of LATS are associated mainly with a delayed onset of action. Biochemists, micro-biologists, endocrinologists, and researchers dealing with microchemistry, bacteriology and immunology will find this collection valuable.

-ContributorsPrefaceContents of Previous VolumesKetogenesis and its Regulation I. Introduction II. Biochemistry of the Ketone Bodies III. Physiological Considerations in Ketone Formation IV. The Practicability of Alloxan Diabetes as a Model for Studying Ketogenesis V. Hepatocellular Regulation of Ketone Body Formation VI. Relation between Ketogenesis and Gluconeogenesis VII. Concluding Comment ReferencesSpontaneous Diabetes and/or Obesity in Laboratory Redents I. Introduction II. Syndromes in Mice (Mus musculus) III. Syndromes in Other Species IV. Features Common to Several Syndromes V. Conclusions References AddendumEthanol-Induced Hypoglycemia I. Introduction II. Characteristics of Ethanol-lnduced Hypoglycemia III. Pathogenesis of Ethanol-lnduced Hypoglycemia ReferencesHormonal Syndromes Associated with Neoplasia I. Introduction II. Hypoglycemia III. Hyperthyroidism IV. Precocious Puberty and Inappropriate Gonadotropin Excretion V. Hyponatremia VI. Erythrocytosis VII. Hypercalcemia VIII. Ectopic ACTH Syndrome IX. Polyfunctional Neoplasms X. Humoral Syndromes XI. Summary ReferencesMeabolic Disorders of the Ovary I. Introduction II. Physiology III. Abnormal Ovarian Metabolism ReferencesThe Nature and Significance of the Long-Acting Thyroid Stimulator I. Introduction II. Nature of LATS III. Significance of LATS ReferencesThyroid Autoantibodies in Thyroid Diseases I. Experimental Autoimmune Thyroiditis II. Methods of Demonstrating Thyroid Antibodies in Humans III. Occurrence of Thyroid Autoantibodies IV. Thyroid Autoantibodies in Other Diseases V. Pathogenic Mechanisms ReferencesErythropoietin I. Historical Overview II. Assay of Erythropoietin III. Chemistry of Erythropoietin IV. Organ of Production V. Site of Action VI. Mechanism of Action VII. The Stimulus for Erythropoietin Production VIII. Renal Excretion IX. The Dynamic Equilibrium of Erythropoiesis X. Endocrine Influences on Erythropoiesis; Role of Erythropoietin XL Clinical Implications of Erythropoietin XII. Conclusion ReferencesAuthor IndexSubject Index