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Medicinal Chemistry: A Series of Monographs, Volume 15: Anticonvulsants discusses the laboratory evaluation, drug disposition, clinical evaluation, and synthesis and design of anticonvulsant drugs. This book is organized into eight chapters. Chapters 1 and 2 provide an overview and neuropharmacological background of anticonvulsants. The laboratory evaluation of compounds is described in Chapter 3, while drug disposition is treated in Chapter 4. The chemistry and biological activities of the various classes of anticonvulsant compounds, such as cyclic ureides, benzopyrans, heterocyclic drugs, and noncyclic anticonvulsants are presented in Chapters 5 to 8. This volume is written specifically for medicinal chemists, biochemists, neurologists, and pharmacologists.
List of ContributorsPreface1 Advances in Anticonvulsant Drug Development Text References2 Neuropharmacology and Treatment of Epilepsy I. Introduction II. Classification of Seizures III. Neurochemistry IV. Neuro Physiology V. Mechanism of Anticonvulsant Drug Action VI. Therapeutic Use of Anticonvulsant Drugs References3 Experimental Evaluation of Anticonvulsants I. Introduction II. Methods III. Hydantoins IV. Barbiturates and Related Compounds V. Oxazolidinediones VI. Succinimides VII. Benzodiazepines VIII. Miscellaneous Anticonvulsants References4 Physiological Disposition of Anticonvulsants I. Introduction II. Diphenylhydantoin and Other Hydantoins III. The Barbiturates IV. Primidone V. The Succinimides VI. The Oxazolidinediones VII. Acetylureas VIII. Carbamazepine IX. The Benzodiazepines X. Acetazolamide XI. Sulthiame References5 Cyclic Ureides I. The Cyclic Ureide Structure II. Barbiturates III. Eterobarb IV. Primidone V. Hydantoins VI. Doxenitoine VII. Oxazolidinediones VIII. Succinimides IX. Addendum: Tables (1-62) References6 Benzopyrans I. Introduction II. Chemistry III. Anticonvulsant Properties IV. Discussion References7 Other Heterocyclic Drugs I. Small-Ring Compounds II. Five-Membered Rings III. Six-Membered Rings IV. Seven-Membered and Larger Rings (Except for Diazepines) V. Diazepines and Related Compounds References8 Noncyclic Anticonvulsants I. General II. Urea Derivatives III. Carbamates IV. Carboxylic Acids and Amides V. Sulfonamides VI. Hydrazones VII. Structure-Activity Relationships ReferencesSubject Index
