Autoimmunity and the Thyroid

Autoimmunity and the Thyroid is a collection of papers presented at an International Satellite Meeting prior to the 7th International Congress of Endocrinology, held at the Mount Sinai Hospital, University of Toronto Medical School on June 29 and 30, 1984. The book provides presentations of participants relating to selected aspects of immune regulation and its role in autoimmune thyroid diseases. Concepts on humoral and cell-mediated immunity mechanisms in the pathogenesis of autoimmune thyroid disease are reviewed; important observations with promising clinical implications in terms of immunogenetics of Graves' and Hashimoto's diseases are presented; and selection of appropriate therapy for Graves' thyrotoxicosis, and the possibility of preventive immunosuppressive and ophthalmopathy therapy are discussed. Endocrinologists, physicians, pathologists, physiologists, and medical researchers will find the book interesting.

ContentsContributors PrefaceHow Thyroid Autoimmunity Was Discovered: Reminiscences of an Autoimmunologist The Immunogenetic Basis of Autoimmune Thyroid Disease The Role of HLA-DR in the Pathogenesis of Autoimmune Thyroid Disease The Role of Human Thyroid Cell la (DR) Antigen in Thyroid Autoimmunity Quantitative and Qualitative Abnormalities in Circulating Lymphocytes in Autoimmune Thyroid Disease anRole of Antigen-Specific Suppressor T Lymphocytes in the Pathogenesis of Autoimmune Thyroid Disease Cytotoxic Mechanisms in Autoimmune ThyroiditisHumoral Aspects of Graves' Disease Significance of Thyroid Autoantibodies in Autoimmune Thyroid Diseases Characterization of Thyroid Autoantibody Synthesizing Cells in Graves' and Hashimoto's Diseases New Methods of Detecting Thyroid Autoantibodies in Sera and Lymphocyte Sypernatants Significance of Thyroid Hormone Autoantibodies New Procedures for Detecting Graves' Immunoglobulins Structure, Synthesis, Cellular Localization and Immunogenicity of the TSH Receptor Significance of Remission in Graves' Disease Postpartum Autoimmune Thyroid Syndromes Short Communications of Research in Progress A Longitudinal Study of Thyroid Autoimmunity and Subclinical Hypothyroidism in a Random Population of Central Italy 317 Lithium Therapy Induces Autoimmune Thyroid Disease Autoimmune Thyroiditis Associated with Melasma in Nonpregnant Women Detection of Antithyroid Membrane Antibody in Graves' Patients Relevance of a Circulating Immune Complex Assay (CIC) to Distinguish between Patients with Autoimmune Thyroid Diseases and Healthy Controls Thyrotropin-Receptor Complex Binding Antibodies in Autoimmune Thyroid Diseases Thyroid Growth Stimulating Immunoglobulins in Patients of an Iodine-Deficient Goiter Region Estimated by 3H-Thymidine Incorporation into Isolated Porcine Thyroid Follicles An Antibody to Eye Muscle in Graves' Ophthalmopathy Analysis of Nonspecific Reaction in Enzyme-Linked Immunosorbent Assay Testing for Human Eye Muscle Specific Antibodies in Graves' Ophthalmopathy and Hashimoto's Thyroiditis Tissue Cross-Reactivity of Mouse and Human Monoclonal and Polyclonal Antibodies against Human Orbital Tissue Antigens Decrease of Peripheral Large Granular Lymphocytes in Graves' Disease T-Suppressor Cell Defects in Sporadic Nontoxic Goiter Disease Lymphocyte Migration Inhibition in Autoimmune Thyroid Disease Cytotoxicity in Hashimoto's Thyroiditis Thyroid Antigen-Induced Leukocyte Procoagulant Activity: A Novel Approach to the Study of Cell-Mediated Immunity in Graves' Disease and Hashimoto's Thyroiditis The Production and Properties of Monoclonal Mouse Antihuman Microsomal Antibodies Auto- and Heteroantibodies against Human Thyroglobulin Exhibit Similar Heterogeneity and Fine Specificities Accumulation of Anti-Thyroglobulin (Tg) Antibody by Normal Thyroid Cells of Monolayer Culture Participation of Ir-gene(s) on the Production of Anti-Thyroid Hormone Antibodies In Situ Expression of HLA Antigens in Graves' Disease Immunoglobulin Allotypes and HLA-DR in Diffuse and Multinodular Simple Goiter Disease, Graves' Thyrotoxicosis, and Endocrine Ophthalmopathy Genetic Markers and Graves' Disease: Study of the Fourth Component Complement Alleles (C4) HLA-Associated Male Susceptibility to Thyroid Autoantibody Production in a Selected Population Influence of HLA-DR4 on the Development of Autoimmune Postpartum Thyroiditis HLA Antigens in Thyroiditis: Differences between Silent and Postpartum Lymphocytic Forms, and Comparison with Subacute and Goitrous Autoimmune Thyroiditis Rabbits Immunized with TSH Produce Thyroid-Stimulating Antibodies Identification of Thyroid Autoantigens and Precipitations of the TSH Receptor by Graves' Disease Immunoglobulins The Development of Monoclonal Antibodies Directed against Anti-TSH Receptor Antibodies Preparation of Biotinylated Receptor Purified