Current Biochemical Research in China

Current Biochemical Research in China presents the Chinese contributions to the biochemical sciences. This book aims to make the situation of biochemical research in China better known to the rest of the world. Organized into 21 chapters, this book begins with an overview of some of the fundamental research of Chinese biochemists, which may be found interesting by colleagues in the western world. This text then presents the investigations of the relationship between structure and function of proteins by synthetic methods. Other chapters provide the comprehensive and scientific compilation of the herb medicines used in China since ancient times. This book discusses as well the correlation of molecular structures of proteins with their biological functions. The final chapter deals with the importance of hemostasis and thrombosis wherein platelets adhere to injured vascular wall and aggregate to form the white hemostatic plug. This book is a valuable resource for biochemists, biophysicists, scientists, and research workers.

ContributorsPreface1. Development of Biochemical Research in China I. Introduction II. General Situation, 1949-1966 III. Research Activities, 1949-1966 IV. 1966 and after References2. Chemical Synthesis and Structure-Function Studies of Bioactive Peptides I. Improvements in Peptide Synthesis II. Structure-Function Studies References3. Trichosanthin: From Chinese Herb Medicine to Ribosome Inactivating Protein I. Introduction II. Structure Investigation III. Relationship of Structure and Function IV. Prospects References4. Structure, Function, and Evolution of Certain Proteins I. Introduction II. Active Products of Porcine Trypsin after Autolysis III. Comparative Study of Primary Structures of Lactate Dehydrogenase Isozymes M4 from Giant Panda and Other Related Mammals IV. Perspective References5. Kinetics of Substrate Reaction during Modification of Enzyme Activity: Theory and Applications I. Introduction II. Kinetics of Substrate Reactions during Enzyme Modification III. Experimental Studies IV. Discussion References6. Mechanism of Snake Muscle Fructose 1,6-Bisphosphatase I. Introduction II. Phosphorylated Intermediate of Fructose 1,6-Bisphosphatase III. Kinetics IV. Regulation of Snake Muscle Fructose 1,6-Bisphosphatase References7. Urokinase and Its Related Proteases in Human Urine I. Introduction II. Benzamidine-Zinc Biaffinity Chromatography of Multiple Forms of Urokinase III. Identification and Properties of Different Molecular Forms of Urokinase IV. Prediction of Conformation of the Two Urokinase Fragments Involved in Inhibitor Binding References8. The Precise Structure of Insulin and Despentapeptide Insulin at High Resolution I. Introduction II. The Precise Structure of Insulin III. Structure of Despentapeptide (B26-30) Insulin IV. What Have We Learned from the Studies of Structure at High Resolution? References9. Correct Pairing of Insulin A and - Chains in Solution and the Formation of the Native from the Scrambled Hormone I. Introduction II. Interaction of the Chains III. Formation of Native Insulin by Protein Disulfide Isomerase IV. Discussion References10. Modern Aspects of Insulin and C Peptide Synthesis I. Introduction II. Insulin A and - Chains III. Proinsulin C Peptide References11. Structure-Function Studies of Insulin I. Semisynthetic Analogs II. Analogs Prepared by Enzymatic Synthesis III. Insulins from Different Species IV. Analogs through Site-Directed Mutagenesis References12. Coupling Problems of Photophosphorylation I. Coupling Mechanism of Photophosphorylation II. The Stoichiometry between Phosphorylation and Electron Transport III. The Degree of Coupling in Vivo and Its Regulation References13. Study on the Lipid-Protein Interactions in -+-ATPase of Mitochondria I. Lipid Structure Related to the Reactivation of Phospholipid-Deficient -+ - ATPase II. Mg2+-Mediated Change in the Physical State of Phospholipid Modulates -+-ATPase Activity References14. A New Function of Proton Pumps in Membrane Fusion I. Introduction II. Proton Pumping Induces Membrane Fusion between Liposomes and Native Membranes Bearing Proton-Pumping Systems III. Proton Pumping Induces Membrane Fusion of Reconstituted Cytochrome C Oxidase Phospholipid Vesicles with Liposomes IV. Is Proton Pumping Induced Membrane Fusion an Energy-Dependent or H+-Consuming Process? V. A New Hypothetical Model for Proton Pumping Induced Membrane Fusion References15. The Interaction of Anisodamine with Biological Membranes I. Introduction II. The Interaction of Anisodamine with Model Membranes III. The Interaction of Anisodamine with Biological Membranes IV. Effect of Anisodamine on the Phase Behavior of Phospholipid Liposomes V.