Microbiology in Clinical Practice

Microbiology in Clinical Practice presents the infections and syndromes caused by micro-organisms. It discusses the management of infective diseases and aetiological agents. It addresses the latex agglutination, immunofluorescent, monoclonal antibody, and nucleic acid probe investigations. Some of the topics covered in the book are the classification and pathogenicity of microbes; classification of bacteria; classification of viruses; classification of fungi; general principles of antimicrobial chemotherapy; antibiotic sensitivity tests; procedures in the laboratory for microbiological diagnosis; and the mode of action of antimicrobial drugs. The resistance to antimicrobial drugs are covered. The microbiological investigations of septicaemia are discussed. The text describes the human immunodeficiency virus infection and AIDS in infants. A study of the congenital immunodeficiency and impaired resistance to infection is presented. A chapter is devoted to the predisposing factors for anaerobic infections. Another section focuses on the infections of the central nervous system. The book can provide useful information to doctors, pathologists, neurologists, students, and researchers.

Foreword to First EditionPreface to Second EditionPreface to First Edition'Priority' ReadingAbbreviations Acknowledgments for Illustrations Section A: General Principles 1 Classification and Pathogenicity of Microbes Classification of Bacteria Classification of Viruses Classification of Fungi Pathogenesis: Factors Affecting 'Virulence' and Spread of Microbes Appendix: Basic Characteristics of Some Important Bacterial Pathogens 2 Use of The Microbiology Laboratory-General Principles Collection of Clinically Relevant Specimens Provision of Essential Clinical Information Prior Discussion with the Microbiologist Collection of Good Quality Specimens Transport of Specimens to the Laboratory Procedures in the Laboratory for Microbiological Diagnosis Antibiotic Sensitivity Tests Appendix 1 : Some Microbiological Methods Appendix 2: Basic Virological Investigations 3 Antimicrobial Chemotherapy-General Principles Mode of Action of Antimicrobial Drugs Spectrum Of Activity Of Antimicrobial Agents General Principles of Use of Antimicrobial Drugs Pharmacokinetic Factors Use of Microbiological Investigations in The Management of Therapy Antibiotic Assays Causes of Failure of Antimicrobial Chemotherapy Resistance to Antimicrobial Drugs Antibiotic Prophylaxis Appendix: Notes on Antimicrobial Drugs Including Some 'New' AntibioticsSection B: Specific Clinical Topics 4 Pyrexia of Undetermined Origin (PUO) Definition of PUO Major Causes of PUO Infective Causes of PUO Investigation of PUO Special Investigations 5 Septicaemia Clinical Features Causative Organisms Microbiological Investigations of Septicaemia Antibiotic Treatment of Septicaemia Prevention of Septicaemia Appendix: Instructions for the Collection of Conventional Blood Cultures 6 Opportunistic Infections Opportunistic' Organisms Opportunistic Conditions Diagnosis of Opportunistic Infections Treatment of Opportunistic Infections Prevention of Opportunistic Infections 7 Obstetric, Perinatal and Neonatal Infections Infections in Pregnancy Perinatal Infections Neonatal and Congenital Infections Puerperal Sepsis and Post-Partum Pyrexia Human Immunodeficiency Virus Infection and AIDS in Infants Gynecological Infections 8 Infections In Children Respiratory Tract Infections Specific Childhood Fevers Some Other Infections in Childhood Congenital Immunodeficiency and Impaired Resistance to Infection Immunization Appendix: List of Infectious Diseases Notifiable in Britain 9 Anaerobic Infections Definition of an Anaerobe Classification of Anaerobes Predisposing Factors for Anaerobic Infections Non-Sporing Anaerobic Infections Clostridial Infections 10 Infections of the Central Nervous System Meningitis Encephalitis Cerebral Abscesses Extradural Spinal Abscess Guillain-Barré Syndrome Congenital Central Nervous System Infections 11 ENT and Eye Infections Ear, Nose and Throat Infections Eye Infections 12 Infections of the Lower Respiratory Tract Normal Flora of the Lower Respiratory Tract Acute Trachea-Bronchitis Infective Exacerbations of Chronic Bronchitis Influenza Para-Influenza Pneumonia Legionnaires5 Disease Aspergillus Broncho-Pulmonary Diseases Farmer's Lung Bronchiectasis Cystic Fibrosis Lung Absc