Epilepsy

Epilepsy: Its Phenomena in Man is a 16-chapter text that covers the wide field of the phenomena of epilepsy in man. This book emerged from the manuscripts presented by the scientific program of an alumni reunion of the Brain Research Institute of the University of California, Los Angeles. The introductory chapters review the role of electricity in the exploration and elucidation of the epileptic seizure, as well as the role of synaptic organization of the cerebral cortex in epilepsy. The succeeding chapters deal with the neuroglial impairment hypothesis, the particular forms of experimental epilepsy in man, and their corresponding surgical treatment. These topics are followed by discussions of the problem of synchronization in the spread of epileptic discharges leading to seizures and the behavioral correlations of generalized spike-wave discharge in the electroencephalogram. Other chapters explore the common anatomy of psychomotor epilepsy and schizophrenia; time of occurrence of seizures; the clinical ictal patterns and electrographic data in partial seizure cases; and the problems of analysis and interpretation of electrocerebral signals in human epilepsy. The concluding chapters consider the developments in direct recordings from epileptogenic regions in the surgical treatment of partial epilepsies. These chapters also examine the golgi survey concerning hippocampal pathology in temporal lobe epilepsy and the structural substrates of seizure foci. This book will prove useful to neuroscientists and the workers in biomedical fields critical for the understanding of epileptogenesis.

-Contributors to this VolumePrefaceHistorical Introduction: The Role of Electricity in the Exploration and Elucidation of the Epileptic Seizure Text ReferencesSynaptic Organization of the Cerebral Cortex and its Role in Epilepsy Neuronal Circuitry of the Cerebral Cortex Role of Disinhibition for Cortical Epileptic Phenomena Visually Evoked Potentials in Patients with Epilepsy Conclusion ReferencesFocal Epilepsy and the Neuroglial Impairment Hypothesis Text ReferencesContribution of Experimental Epilepsy to Understanding Some Particular Forms in Man Clinical Cases New Experimental Data from the Photosensitive Papio papio Correlations between Clinical Data and Experimental Results Obtained from Papio papio ReferencesDepth Recordings in Man in Temporal Lobe Epilepsy General Methodology Discussion ReferencesTactical Considerations Leading to Surgical Treatment of Limbic Epilepsy Decisions in Selecting Patients for Surgical Consideration The Criteria Adopted for Depth Electrode Implantation Decisions Encountered in Connection with Depth Electrode Implantation Additional Methods of Localization Summary ReferencesThe Problem of Synchronization in the Spread of Epileptic Discharges Leading to Seizures in Man Definition of the Concept of Synchronization Observations on Humans Experimental Results on Cortical Synchronization Anatomical Findings Supporting Columnar Organization of the Cortex Propagation of Seizure Waves in the Cortex: Synchronization ReferencesElectrical Seizure Discharges within the Human Brain: The Problem of Spread Method Comments Summary ReferencesBehavioral Correlates of Generalized Spike-Wave Discharge in the Electroencephalogram Spontaneous Behavior Experimental Behavior Discussion Concluding Remarks ReferencesPsychomotor Epilepsy and Schizophrenia: A Common Anatomy? Clinical Studies Experimental Studies Pharmacological Studies Anatomical and Histochemical Studies Physiological Studies Summary ReferencesCircadian Cycles and Seizures Time of Occurrence of Seizures Interictal Electroencephalographic Abnormality Sleep Deprivation Photic Stimulation Effects of Seizures on Normal Circadian Cycles Conclusions ReferencesClinical Ictal Patterns and Electrographic Data in Cases of Partial Seizures of Frontal-Central-Parietal Origin Patient Material, Method, and Generalities Results Discussion Summary ReferencesProblems of Analysis and Interpretation of Electrocerebral Signals in Human Epilepsy: A Neurosurgeon's View Procedure Duration of the Stereoelectroencephalographic Recording Recording of Ictal Electrical Activity Recording of Interictal Abnormalities Conclusions Summary ReferencesDevelopments in Direct Recordings from Epileptogenic Regions in the Surgical Treatment of Partial Epilepsies Methods Results Discussion Summary ReferencesHippocampal Pathology in Temporal Lobe Epilepsy. A Golgi Survey Introductory Anatomical Comments Pathological Changes in the Hippocampus Pathology of the Dentate Granules Neuroglia Conclusions ReferencesStructural Substrates of Seizure Foci in the Human Temporal Lobe(A Combined Electrophysiological Optical Microscopic and Ultrastructural Study) Materials and Methods Clinical Observations Ultrastructural Studies Discussion Summary ReferencesAuthor IndexSubject Index

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