Immunointervention in Autoimmune Diseases

Immunointervention in Autoimmune Diseases is a collection of papers presented at the 1988 International Meeting by the same title, held in Paris, France. This text contains 21 chapters and begins with surveys of the role of antigen in autoimmune responses and the moving boundaries between physiology and pathology of immunity. The succeeding chapters deal with the regulation, immunosuppressive therapy, infections, and immunointervention of autoimmune disorders. These topics are followed by discussions of specific immunosuppressive therapy for a particular disease, including type I diabetes, T-cell leukemia, and systemic lupus erythomatosus. This work also explores the principles of allograft, the use of monoclonal antibody, and OKT3. The remaining chapters consider the maintenance of autoimmunity and the risk/benefit in immunointervention for autoimmune diseases. This book will prove useful to immunologists, pathologists, physiologists, and researchers.

IntroductionThe Role of Antigen in Autoimmune Responses with Special References to Changes in Carbohydrate Structure of IgG in Rheumatoid ArthritisAutoimmunity: The Moving Boundaries Between Physiology and PathologyCyclosporine A and the Regulation of Autoimmune DiseaseHazards of Cyclosporine A Therapy and Recommendations for its UseCancer is a Long-Term Hazard of Immunosuppressive TherapySome Viral Infections and Related Disorders Associated with Long-Term Immunosuppressive TreatmentsApproach to the Use of Antigen Non-Specific Immunosuppression in Systemic Lupus Erythematosus and Other Rheumatic Autoimmune DiseasesImmunointervention in Skin DisordersTherapeutic Immunosuppression in Type I (Insulin-Dependent) DiabetesThe Clinical Use of Immunosuppressants in the Treatment of Putative Autoimmune Intra-Ocular DiseasesA Theoretical Framework for Self-Tolerance and its Relevance to Therapy of Autoimmune DiseaseClinical Use of OKT3: The Role of Cytokine Release and XenosensitizationThe Multichain Interleukin-2-Receptor: A Target for Immunotherapy of Patients with Adult T-cell Leukemia, Autoimmune Disorders and Individuals Receiving AllograftsAnti-IL-2-R Monoclonal Antibody in Allograft RecipientsTherapy of Autoimmune Diseases with Monoclonal Antibodies to Class II Major Histocompatibility Complex Antigens: The Role of T LymphocytesIdiotype Selection is an Immunoregulatory Mechanism which Contributes to the Pathogenesis of Systemic Lupus ErythematosusInduction of SLE-Like Disease in Naive Mice with a Monoclonal Anti-DNA Antibody Derived from a Patient with Polymyositis Carrying the 16/6 IDCellular Mechanisms in Immune Tolerance and Treatment of Autoimmune Disease: Studies Using Total Lymphoid Irradiation (TLI)Maintenance of AutoimmunityThe Risk/Benefit Ratio in Immunointervention for Autoimmune Diseases