Metabolic Bone Disease

Metabolic Bone Disease, Volume II describes the clinical disorders of bone and mineral metabolism characterized by elevated levels of circulating parathyroid hormone. This book emphasizes the relationship between hormonal synthesis, biological activity, and abnormalities in specific clinical syndromes. The metabolism and structure-function relationships of parathyroid hormone and other revealing interactions with specific receptors in target organs are also elaborated in this publication, including a basis for some understanding of the parathyroid hormone and vitamin D-"resistant states. Other topics discussed include the fundamental considerations of the physiology and biochemistry of parathyroid hormone; pathogenesis of renal osteodystrophy; and metabolic aspects of Paget's disease. This publication also covers the effects of hypercalcemia and normocalcemic disorders of mineral metabolism. This volume is beneficial to clinicians and students concerned with metabolic bone diseases.

List of ContributorsPrefaceContents of Other Volumes1 Parathyroid Physiology and Primary Hyperparathyroidism I. Introduction II. Fundamental Considerations of the Physiology and Biochemistry of Parathyroid Hormone III. Primary Hyperparathyroidism References2 Renal Osteodystrophy I. Introduction II. Pathogenesis of Renal Osteodystrophy III. Clinical and Radiological Correlates IV. Soft Tissue Calcification V. Dialysis Bone Disease VI. The Nature of the Bone Lesions VII. Therapeutic Management References3 Hypoparathyroidism I. Postoperative Hypoparathyroidism II. Nonsurgical Damage to the Parathyroid Glands III. Functional Hypoparathyroidism of Diverse Etiology in the Newborn IV. Secondary Hypoparathyroidism Due to Hypercalcemia, with Special Reference to the Newborn Infant of a Hyperparathyroid Mother V. Secondary Hypoparathyroidism Due to Hypermagnesemia VI. Acquired Metabolic Resistance to Parathyroid Hormone VII. Hypoparathyroidism Due to the Secretion of Ineffective Parathyroid Hormone VIII. Idiopathic Hypoparathyroidism IX. Pseudohypoparathyroidism and Related Disorders X. Signs and Symptoms of Hypocalcemia XI. Biological Findings XII. Treatment XIII. Concluding Remarks References4 The Thyroid Gland in Skeletal and Calcium Metabolism I. Introduction II. The Thyroid Hormones: T3 and T4 III. Calcitonin IV. Recent Developments References5 Paget's Disease of Bone I. Introduction II. Historical Aspects III. Incidence and Epidemiology IV. Histopathology V. Focal Manifestations VI. Complications VII. Metabolic Aspects of Paget's Disease VIII. Systemic Complications and Associated Diseases IX. Drug Treatment X. Etiology References6 Disorders of Mineral Metabolism in Malignancy I. Introduction II. Effects of Hypercalcemia III. Clinical Occurrence IV. Pathogenesis of Tumor-Associated Hypercalcemia V. Treatment of Hypercalemia References7 Metabolic Bone Disease in Children I. Growth and Development of Skeleton II. Differential Diagnosis of Hypercalcemia III. Differential Diagnosis of Hypocalcemia IV. Normocalcemic Disorders of Mineral Metabolism V. Bone Disease in Disorders of Renal Function ReferencesIndex