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This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress.MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles.
- Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development
- Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development
- Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines
Overview of immune system. Innate immunity and special role of antigen presenting cells.Immunity and size.Introduction to the vaccines.Current challenges in vaccine development.Growing role of nanotechnologyNanotechnology in medical researchNanoparticle based peptide vaccinesLiposome as nano- and microvaccinesLipid in peptide vaccine (excluding liposomes)Nanoadjuvants for peptide based vaccinesNanopatches for vaccine deliveryOral vaccine delivery Nano- and microtechnology in skin delivery of vaccinesNasal vaccine deliveryNanoparticles for cancer targeting vaccines by polymer based nanovaccinesLipidic microparticles for vaccine deliveryPolymeric microparticles for vaccine delivery
