Physiological and Clinical Aspects of Oxygenator Design

Physiological and Clinical Aspects of Oxygenator Design documents the proceedings of the Seminar on Advances in Oxygenator Design held at Rungstedgaard in Copenhagen, on 15-20 June 1975. It has been the triple purpose of this seminar to promote interdisciplinary contact between European scientists in the field of extracorporeal oxygenation, to give a picture of the state of the art, and to give indications for the trends for future research. This volume is organized into seven parts. Part I contains papers on the dimensional conditions for oxygenators. Part II presents studies on oxygenator construction. Part III is devoted to experimental methods of oxygenation. The presentations in Part IV focus on hematological aspects such as the microrheology of erythrocytes and platelets, and the effect of unphysiological blood flow on circulating cells. Part V deals with tissue factors, including oxygen consumption at the cellular level. Part VI covers measurements during extracorporeal circulation. Part VII discusses compatibility problems of foreign surfaces, covering materials from membrane oxygenators and approaches to blood-compatible materials.

PrefaceIntroductory remarks List of Contributors Advances in oxygenator design: past, present and future Dimensional Conditions for Oxygenators Operational conditions underlying the design of membrane oxygenators Scaling rules for flat plate and hollow fiber membrane oxygenators for total bypass Introduction Notations Model definition and related gas transfer parameters Scaling rules Membrane oxygenator performance under varying conditions Discussion Appendix References Correlation of effects of blood flow rate, viscosity and design features on artificial lung performance Introduction Effects of blood flow rate Viscosity Design features: Compliance effects Design features: Port resistance Morphological evidence by casting Thrombus formation Cannulae Discussion Summary Acknowledgments References Fluid mechanical problems in membrane oxygenators Introduction Symbols Multiple pipe membrane oxygenator Hydrophilic membrane oxygenator Electromagnetic mixing Conclusions References Oxygenator Construction The Taylor-Vortex membrane oxygenator: design analysis based on a predictive correlation for oxygen transfer Introduction Symbols Experimental methods Mass transfer correlation Design analysis Discussion Acknowledgments References Annular membrane oxygenator with tangential flow.