Programmed Cell Death in Cancer Progression and Therapy

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically. With this book, we give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, this book will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeutics.

Introduction Chapter 1: Cell Death: History and Future by Zahra Zakeri and Richard A. Lockshin Chapter 2: Caspase Mechanisms by Guy S. Salvesen and Stefan J. Riedl Chapter 3: The Mitochondrial Death Pathway by Anas Chalah and Roya Khosravi-Far Chapter 4: Apoptotic Pathways in Tumor Progression and Therapy by Armelle Melet, Keli Song, Octavian Bucur , Zainab Jagani, Alexandra R. Grassian and Roya Khosravi-Far Chapter 5: Therapeutic Targeting of Death Pathways in Cancer - Mechanisms for activating cell death in cancer cells by Ting-Ting Tan and Eileen White Chapter 6: Overcoming Resistance to Apoptosis in Cancer Therapy by Peter Hersey, X.D. Zhang, N. Mhaidat Chapter 7: TRAIL Receptors: Targets for Cancer Therapy by Robin C. Humphreys and Wendy Halpern Chapter 8: Rational Design of Therapeutics Targeting the Bcl-2 Family - Are some cancer cells primed for death but waiting for a final push? by Victoria Del Gaizo Moore and Anthony Letai Chapter 9: Autophagy and Tumor Suppression - Recent advances in understanding the link between autophagic cell death pathways and tumor development by Shani Bialik and Adi Kimchi Chapter 10: Regulation of Programmed Cell Death by the p53 Pathway by Kageaki Kuribayashi and Wafik S. El-Deiry Chapter 11: Regulation Of Programmed Cell Death by Nf-k B and its Role in Tumorigenesis and Therapy by Yongjun Fan, Jui Dutta, Nupur Gupta, Gaofeng Fan and Céline Gélinas Chapter 12: Targeting Proteasomes as Therapy in Multiple Myeloma by Dharminder Chauhan, Teru Hideshima and Kenneth C. Anderson Chapter 13: Histone Deacetylase Inhibitors: Mechanisms and Clinical Significance in Cancer - HDAC inhibitor-induced apoptosis by Sharmila Shankar and Rakesh K. Srivastava Chapter 14: RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches by Derek M. Dykxhoorn, Dipanjan Chowdhury, Judy Lieberman Chapter 15:Cancer Stem Cells and Impaired Apoptosis by Zainab Jagani and Roya Khosravi-Far