Sickle Cell Disease in Sub-Saharan Africa

This important collection provides an epidemiological perspective on the continuing scope of sickle cell disease (SCD) in sub-Saharan Africa, alongside the clinical attempts to provide comprehensive care in a resource-limited setting. The book moves from a clinical profile of SCD to screening for the disease and ongoing patient care. There are chapters on pain management, organ failure, infections and transfusions, as well as nutrition and neurocognitive complications. The book concludes with chapters on anti-sickness medication, cell transplantation and nursing care. The first in a two-volume set offering a multi-disciplinary perspective on SCD, this is a comprehensive resource that applies clinical knowledge to the practical challenges faced in sub-Saharan Africa. It will be important reading for medical students taking courses in haematology as well as those studying Public Health in sub-Saharan Africa. Practitioners in the region will also find it invaluable in developing their understanding of this pervasive disease.

Baba Inusa, MBBS (ABU 1984), FMCPaed (Nigeria, 1992), FRCPCH (UK, 1997) is Professor of paediatric haematology, Evelina London Children's Hospital, Guy's and St Thomas NHS Foundation Trust. Kanayo Nwankwo, MD, is the Chief Resident and a lifespan sickle cell advocate, currently serving at Brookdale University Hospital in Brooklyn NY. Nkechikwu Azinge-Egbiri, LLB (Hons), BL, LLM, PhD (Warwick), is a Lecturer at the School of Law, Lancaster University and Founder of the Sickle Cell Aid Foundation (SCAF), a youth-led NGO she established to raise awareness of Sickle Cell Disease (SCD) and support those living with it. Bukola Bolarinwa is a qualified legal practitioner with an LLM in International Economic Law from the University of Warwick and LLB from the University of Leicester.

Introduction Chapter 1 - The Clinical Epidemiology of Sickle Cell Disease in Sub-Saharan Africa Chapter 2 - Laboratory Profile of Sickle Cell Disease Chapter 3 - Pre-implantation Genetic Diagnosis for Prevention of Sickle Cell Disorder: Current Trends and Barriers Chapter 4 - The State of Newborn Screening for Sickle Cell Disease in Low and Middle Income Countries Chapter 5 - Routine Comprehensive Care for Children with SCD Chapter 6 - Pediatric to Adult Transition Care for Patients with Sickle Cell Disorder Chapter 7 - Neurocognitive Complications of Sickle Cell Disease in Africa Chapter 8 - Overview of Organ Dysfunction in Sickle Cell Disease Chapter 9 - Management of Pain in Sickle Cell Disease Chapter 10 - Management of Infections and Fever in Sickle Cell Disease (SCD) Chapter 11 - Transfusion in Sickle Cell Disease (SCD): Complications Including Iron Overload Chapter 12 - Pregnancy in women with Sickle Cell Disorder Chapter 13 - Sickle Cell Disease and Nutrition Chapter 14 - Hydroxyurea in the management of Sickle Cell Disease in Africa Chapter 15 - Niprisan and Other Homegrown Antisickling Medications: Successes and Challenges Chapter 16 - Investigational Therapies and Advances in Science for SCD: A Glimmer of Hope Chapter 17 - Hematopoietic Cell Transplantation for Sickle cell Disease: A global perspective Chapter 18 - Nursing Care in Sickle Cell Disease: Lessons from East Africa Chapter 19 - Access to Blood Products for SCD Warriors in Nigeria - Challenges and Opportunities

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