Special Topics and General Characteristics

Infectious Blood Diseases of Man and Animals: Diseases Caused by Protista, Volume I: Special Topics and General Characteristics focuses on the critical analysis of metabolic, immuno-pathologic, taxonomic, ultrastructural, locomotor, ecologic, zoonotic, and other features of the protistan blood diseases. The selection first offers information on ecology and host-parasite relationship; basis of host cell-parasite specificity; and abrogation of immunological tolerance as a model for autoimmunity. Topics include interactions in disease transmission, types of host-parasite relationship, and experimental abrogation of tolerance. The text then takes a look at autoimmune response and pathogenesis of blood parasite disease and blood parasite antigens and antibodies. The publication examines the zoonotic potential of blood parasites, including diseases caused by bacteria and spirochetes and trypanosomiasis. The text then focuses on the cultivation and nutritional requirements and biological leads to chemotherapy of blood Protista. Discussions focus on organisms developing within the blood cells; energy metabolism and chemotherapeutic targets; and protozoa developing primarily in the plasma. The book is a valuable reference for readers interested in the diseases caused by Protista.

List of ContributorsForewordPrefaceContents of Volume IIPart I: Special Topics 1. Ecology and Host-Parasite Relationship I. Types of Host-Parasite Relations II. Relation of Vertebrate Host Group to Parasite Group III. Patterns of Host Response to Blood Parasites IV. Relation of Parasite Group to Vector Group V. Interactions in Disease Transmission VI. Landscape Epidemiology References 2. Basis of Host Cell-Parasite Specificity I. Introduction II. Factors Affecting Host Cell-Parasite Specificity in the Vertebrate Host III. Susceptibility of Arthropod Vectors to Protozoan Parasites IV. Conclusion References 3. Abrogation of Immunological Tolerance as a Model for Autoimmunity I. Introduction II. The Immunological Recognition System III. Experimental Abrogation of Tolerance IV. Conclusions References 4. Autoimmune Response and Pathogenesis of Blood Parasite Diseases I. The Immunological Basis of Anemia in Erythrocytic Infections II. Concepts of Autoimmune Response III. Immunopathology IV. Protection Resulting from the Autoimmune Response References 5. Blood Parasite Antigens and Antibodies I. Plasmodia II. Trypanosomes III. Theileria IV. Babesia V. Anaplasma VI. Eperythrozoon and Haemobartonella References 6. Zoonotic Potential of Blood Parasites I. Introduction II. Definitions III. Diseases Caused by Bacteria and Spirochetes IV. Trypanosomiasis V. Malaria VI. Babesiosis ReferencesPart II: General Characteristics of the Blood Protists 7. Definition and Classification I. The Concept of Protista II. Problems of Protistan Taxonomy III. Rules of Nomenclature IV. Definition of Blood Protists V. Skeletal Scheme of Classification VI. Annotated Bibliography 8. Cultivation and Nutritional Requirements I. Introduction II. Protozoa Developing Primarily in the Plasma: The Hemoflagellates III. Organisms Developing within the Blood Cells References 9. Some Biological Leads to Chemotherapy of Blood Protista, Especially Trypanosomatidae I. Introduction: Need for Better Screening Methods for Antiprotozoal Agents II. Pitfalls in Screening for Antiprotozoal Agents III. The Antimetabolite Approach: Ways to Identify New Metabolites as Potential Chemotherapeutic Targets IV. Seductions of Molecular Biology; DNA Binding V. Energy Metabolism and Chemotherapeutic Targets VI. Prospects References 10. The Fine Structure I. Introduction II. Protozoa Invading Blood Cells III. Protozoa Not Invading Blood Cells (Trypanosomes) IV. Conclusion and General Remarks References 11. Development and Reproduction (Vertebrate and Arthropod Host) I. Introduction II. The Trypanosomatidae III. The Plasmodiidae References 12. Preservation and Storage in Vitro I. Preservation by Freezing II. Preservation by Freeze-Drying III. Results Obtained References 13. Investigational Problems and the Mechanisms of Inheritance in Blood Protozoa I. Introduction II. Cytological Analysis of Genetic Systems III. Genetic Markers IV. Developmental Genetics V. Population Dynamics References 14. Locomotion of Blood Protists I. Hydrodynamic and Thermodynamic Problems II. Locomotion by Active Body Flections III. Locomotion of Flagellated Protozoa IV. Summary ReferencesAuthor IndexSubject Index

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