The Handbook of Cannabis Therapeutics

Learn the facts behind the pharmacology and pharmacokinetics of controversial cannabis therapeutics The Handbook of Cannabis Therapeutics: From Bench to Bedside sets aside the condemnation and hysteria of society's view of cannabis to concentrate on the medically sound aspects of cannabis therapeutics. The world's foremost experts provide a reasoned, thoroughly researched overview of the controversial subject of cannabis, from its history as a medicine through its latest therapeutic uses. The latest studies on the botany, history, biochemistry, pharmacology, toxicology, clinical use for various illnesses such as AIDS, epilepsy, and multiple sclerosis, and side effects of marijuana are all examined and discussed in depth. This comprehensive resource is a compendium of articles from the Journal of Cannabis Therapeuticswith additional contemporary commentary. It presents startling research that explores and supports the medicinal value of cannabis use and its derivatives as a valid therapeutic resource for pain and inflammation, for several illnesses less responsive to other therapies, and even for certain veterinary uses. Cannabinoids such as nabilone, THC, levonantradol, ajulemic acid, dexanabinal, and others are extensively described, with a review of new indications for cannabinoid pharmaceuticals. The book is carefully referenced to encourage your examination of previous studies and provides tables and figures to enhance understanding of information. The Handbook of Cannabis Therapeutics discusses: - the uses of cannabis in Arabic, Greek, Roman, and early English medicines - absorption rates - pharmacokinetics - pharmacodynamics - separate extracts versus the use of cannabis in its entirety - the therapeutic value of the endocannabinoid system - cannabinoids and newborn feeding - a comparison of smoking versus oral preparations - clinical research data on eating cannabis - therapeutic uses as appetite stimulant - treatments in obstetrics and gynecology - medicinal treatments used in Jamaica - the use of cannabis in the treatment of multiple sclerosis - the benefits versus the adverse side effects of cannabis use The Handbook of Cannabis Therapeutics is a reference work certain to become crucial to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public.

Franjo Grotenhermen, Ethan B. Russo

- About the Editors - Contributors - Foreword - Introduction (Franjo Grotenhermen) - PART I: HISTORICAL NOTES - Chapter 1. The Therapeutic Use of Cannabis sativa L. in Arabic Medicine (Indalecio Lozano) - Introduction - Materials and Methods - Results - Conclusion - Update - Chapter 2. Cognoscenti of Cannabis I: Jacques-Joseph Moreau (1804-1884) (Ethan B. Russo) - Chapter 3. Cognoscenti of Cannabis II: Simeon Seth on Cannabis (David Deakle) - Chapter 4. The Medical Use of Cannabis Among the Greeks and Romans (James L. Butrica) - Introduction - Absence of Mention - The Emergence of Cannabis - Appendix I: Passages Discussing Wild Cannabis Possibly Misunderstood As Discussing Domesticated Cannabis - Appendix II: Cannabis in Veterinary Medicine - Update - Chapter 5. A Homelie Herbe: Medicinal Cannabis in Early England (Vivienne Crawford) - Introduction - Cannabis History in England - The Modern Era - Update - Chapter 6. Future of Cannabis and Cannabinoids in Therapeutics (Ethan B. Russo) - Introduction - New Indications for Cannabinoid Pharmaceuticals - Cannabinoids and Neuroprotection - Spasmodic Disorders - Forbidden Territories - Update - PART II: PHARMACOLOGY AND PHARMACOKINETICS - Chapter 7. Clinical Pharmacokinetics of Cannabinoids (Franjo Grotenhermen) - Introduction - Pharmacokinetics of 9-THC - Absorption - Distribution - Metabolism - Course of Plasma Concentration of THC and Metabolites - Elimination - Time Effect Relationship - Pharmacokinetics of Other Cannabinoids - Metabolic Interactions - Conclusion - Chapter 8. Clinical Pharmacodynamics of Cannabinoids (Franjo Grotenhermen) - Introduction - Mechanism of Action - Cannabinoid Receptors - Endocannabinoids - Pharmacological Effects of THC - Toxicity - Psyche, Cognition and Behavior - Central Nervous System and Neurochemistry - Circulatory System - Some Other Organ Systems and Effects - Pharmacological Activity of THC Metabolites - Pharmacological Effects of Other Cannabinoids - Tolerance and Dependency - Therapeutic Uses - Hierarchy of Therapeutic Effects - Basic Research Stage - Drug Interactions - Conclusions - Update - Chapter 9. Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts? (John M. McPartland and Ethan B. Russo) - Introduction - Materials and Methods - Results and Discussion - Cannabinoids - Terpenoids - Flavonoids - Conclusions - Update - PART III: ENDOCANNABINOIDS AND CANNABINOID RECEPTORS - Chapter 10. The Endocannabinoid System: Can It Contribute to Cannabis Therapeutics? (Vincenzo Di Marzo) - The Endocannabinoid System - Endocannabinoid Pharmacology: More Than Meets the Eye - Levels of Endocannabinoids in Tissues: Physiology and Pathology - New Drugs from the Endocannabinoid System: Curative or Palliative? - Update - Chapter 11. Cannabinoids and Feeding: The Role of the Endogenous Cannabinoid System As a Trigger for Newborn Suckling (Ester Fride) - Interactions of the Endocannabinoids System with Hormones Regulating Food Intake - Endocannabinoids in Food Substances - Developmental Aspects of the Endocannabinoid-CB1 Receptor System - Blockade of CB1 Receptors in Newborn Mice - Mechanisms of the CB1 Receptor Blockade-Induced Growth-Stunting Effects - Conclusions - Update - PART IV: MEDICINAL USES - Chapter 12. Mariju

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