The Inflammatory Process

The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from cell surface phenomena and connective tissue to the role of the formed elements of the blood in inflammatory states, particularly in the light of the rapidly burgeoning literature on platelet physiology. The life history and functional capacities of leukocytes are also examined, along with chemotaxis, phagocytosis, and the mechanisms responsible for tissue damage in inflammation. Comprised of 10 chapters, this volume begins with an overview of the experimental approach to the study of inflammation, followed by a discussion on the biochemistry of the mammalian plasma membrane. The reader is then introduced to cell injury; chemotaxis; phagocytosis; and lysosomal mechanisms in the inflammatory process. Subsequent chapters deal with the inflammatory process at the cellular level, paying particular attention to neutrophil leukocytes; the metabolism and physiology of mononuclear phagocytes; the role of platelets in inflammatory reactions; and structural and biochemical characteristics of mast cells. This book will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.

List of ContributorsPrefacePreface to First EditionContents of Other VolumesPart I. Inflammatory Process at the Molecular Level Chapter 1. The Experimental Approach to the Study of Inflammation I. Introduction II. The Gross Pathology of Inflammation III. The Light Microscope and the Study of Inflammation IV. Bacteriology and Immunology V. Chemotaxis VI. Phagocytosis VII. The Physiological Approach to Problems of Inflammation VIII. Chemical Mediators of Inflammation IX. The Electron Microscope and Changes in Ultrastructure X. Conclusions XI. Summary References Chapter 2. Biochemistry of the Mammalian Plasma Membrane I. Introduction II. Morphological Background III. The Chemical and Enzymatic Composition of Plasma Membranes IV. Isolation of Plasma Membrane Proteins V. Biosynthesis of the Plasma Membrane VI. Molecular Organization of the Plasma Membrane References Chapter 3. Cell Injury I. Introduction II. Progression of Changes in Lethal Injury III. Chronic Cell Injury References Chapter 4. Lysosomal Mechanisms in the Inflammatory Process I. Introduction II. Formation, Classification, and Fate of Lysosomes III. Structure and Contents of Lysosomes IV. Morphology V. Functions of Lysosomes References Chapter 5. Chemotaxis I. Introduction II. Chemotaxis in Bacteria III. Chemotaxis in Plants IV. Chemotaxis in Lower Animal Forms V. Tissue Culture Studies: Chemotactic Factors in Tumors VI. Chemotaxis in White Blood Cells VII. Possible Modifying Mechanisms in Chemotaxis VIII. Conclusion IX. Summary References Addendum Chapter 6. Phagocytosis I. Introduction II. General Aspects of Phagocytosis III. Metabolism during Phagocytosis IV. Clinical Abnormalities of Cellular Host Defense Addendum ReferencesPart II. Inflammatory Process at the Cell Level Chapter 7. Neutrophil Leukocytes I. Introduction II. Terminology and Morphology III. Formation, Distribution, and Fate of Neutrophils IV. The Nature of Neutrophil Granules V. Metabolism of Neutrophils VI. Physiology of Neutrophils VII. Neutrophil Functions VIII. Abnormal Neutrophils References Chapter 8. The Metabolism and Physiology of the Mononuclear Phagocytes I. Introduction II. Life History III. Morphology IV. Maturation V. Endocytosis VI. Macrophages and Host Defense VII. Macrophage and the Immune Response References Chapter 9. Platelets I. Introduction II. Reactions in Hemostasis: Effects of Thrombin, Collagen, Subendothelial Microfibrils, ADP, and Epinephrine III. Reaction of Platelets with Foreign Materials IV. Inhibitors of Platelet Aggregation and Release: Similarities Between the Reactions of Platelets and Other Cells V. Platelets in Other Inflammatory Reactions References Chapter 10. Structural and Biochemical Characteristics of Mast Cells I. Introduction II. Origin and Distribution of Mast Cells III. Normal Tissue Mast Cells; Neoplastic Mast Cells IV. Mast Cell Cytology V. Biochemistry of the Mast Cells VI. Functional View of the Tissue Mast Cell VII. Mast Cells in Pathological Disorders VIII. Concluding Remarks ReferencesAuthor IndexSubject Index