Viruses, Evolution and Cancer Basic Considerations

Viruses, Evolution and Cancer: Basic Considerations focuses on comparative biology and evolutionary aspects of DNA and RNA oncogenic viruses. Organized into seven parts, this book begins with a discussion on the host-cell-virus relationships. Some chapters follow that discuss the comparative aspects of DNA and RNA oncogenic viruses. This work also elucidates the effects of oncogenic viruses on cell surface metabolism. Other chapters explore the comparative viral oncology, comparative immunology of oncogenic viruses, and evolution of viruses. This book will be an invaluable material both to those concerned in the scientific and medical problems of cancer and will benefit all who are interested in virology and oncology.

List of Contributors Preface IntroductionPart I Host-Cell-Virus Relationships Chapter 1. Host-Virus Relationship at the Embryonic Level I. Introduction II. Differentiation of Early Mammalian Embryos in Vitro III. Endogenous Viral Particles in Mouse Embryos IV. Interaction of Oncogenic Viruses with Mouse Embryos References Chapter 2. DNA Transfer and Virus-Cell Relationships I. Introduction II. Rescue of SV40 from Transformed Cells III. Alteration of Hamster Cells by Exposure to Simian Cell DNA IV. Formation of "Heterologous" SV40 Pseudovirions V. Discussion and Forecast References Chapter 3. Viruses with Separately Encapsidated Complementary DNA Strands I. Introduction and Nomenclature II. Adeno-associated Satellite Viruses (ASV, AAV) and Densonucleosis Virus (DNV) III. Adeno-associated Satellite Viruses and Densonucleosis Virus and Disease IV. Adeno-associated Satellite Viruses and Densonucleosis Virus and Cancer V. Conclusions References Chapter 4. The Epstein-Barr Viral Genome and Its Interactions with Human Lymphoblastoid Cells and Chromosomes I. The Virus II. Viral DNA III. Techniques of Nucleic Acid Hybridization IV. Interactions of the Viral Genome in Various Tissues V. Problems and Conclusions ReferencesPart II Comparative Aspects of DNA Oncogenic Viruses Chapter 5. Comparison of Genome Replication Mechanisms of Oncogenic DNA Viruses I. Introduction II. Papovaviruses III. Adenoviruses IV. Concluding Remarks References Chapter 6. Early Proteins of Oncogenic Papovaviruses I. Introduction II. Early and Pre-early Functions III. Intranuclear and Plasma Membrane Events IV. Intranuclear Immunological Changes after Virus Infection V. Are Early Intranuclear Antigens Polypeptides of Viral Information? VI. Identification and Attempts to Purify Early Viral Proteins VII. Viral Enzymes: Possible Candidates References Chapter 7. Adenovirus Genes and Cancer I. Introduction II . Conditionally Lethal Temperature-Sensitive (ts) Mutants of Type 5 Adenovirus III. Temperature-Sensitive Mutants of Type 12 Adenovirus IV. Intertypic Complementation with Type 5 and Type 12 ts Mutants V. Transformation of Rat Embryo Cells by Type 5 Adenoviruses VI. Perspectives References Chapter 8. Herpesvirus Etiology of Abnormal Growth I. Introduction II. Oncogenicity of Animal Herpesviruses III. Association of Human Herpesviruses with Neoplasia IV. Transformation by Human Herpesviruses V. Role of the Herpesvirus Genome in Oncogenicity VI. Future Expectations References Part III Comparative Aspects of RNA Oncogenic Viruses Chapter 9. Replication and Integration of the Genome of Oncornaviruses I. Introduction II. The Viral Genome III. The DNA "Provirus" IV. The Cryptic Viruses V. Discussion References Chapter 10. Comparison and Evolution of RNA Tumor Virus Components I. Introduction II. Materials and Methods III. Results IV. Discussion References Chapter 11. Genetics and Biology of Murine Leukemia Virus I. Introduction II. Isolation of ts Mutants of MuLV III. Complementation by ts Mutants of MuLV IV. Characterization of ts Mutants of MuLV V. Genetic Recombination in MuLV VI. Models of the Genome of MuLV VII. Evidence That the RNA of the Virion is Segmented VIII. Conclusions References Chapter 12.