Advances in Metabolic Disorders

Advances in Metabolic Disorders, Volume 5 covers the developments in the study of metabolic disorders. The book discusses the hypothalamic control of the secretion of adenohypophysial hormones; the adrenocortical control of epinephrine synthesis in health and disease; and the role of the renin-angiotensin system in the physiological control of aldosterone secretion. The text also describes the general metabolic and systemic effects of progesterone and synthetic progestins, and the experimental and clinical studies of the role of the thymus glands in the development and expression of immune functions. The control of glucose metabolism in the human fetus and newborn infant, as well as the dynamics and regulation of the human adipose tissue are also considered. The book concludes by encompassing the possible association between several metabolic abnormalities and coronary artery disease. Endocrinologists and biochemists will find the text invaluable.

ContributorsContents of Previous VolumesHypothalamic Control of the Secretion of Adenohypophysial Hormones I. Introduction II. Chemistry of the Hypothalamic Releasing Factors III. Mechanisms of Action of the Hypothalamic Factors IV. Conclusions ReferencesAdrenocortical Control of Epinephrine Synthesis in Health and Disease I. Introduction II. Morphology of the Mammalian Adrenal Gland III. Catecholamine Biosynthesis in Neurons and Chromaffîn Cells IV. Adrenocortical Control of Adrenomedullary Function V. PNMT Activity in the Brain VI. The Adrenal Cortex and Epinephrine Synthesis in Nonmammalian Vertebrates VII. Clinical Implications ReferencesThe Relationship Between Angiotensin and Aldosterone I. The Renin-Angiotensin System in the Physiological Control of Aldosterone Secretion II. Clinical Implications III. Conclusions ReferencesThe Metabolic Influence of Progestins I. Introduction II. Electrolyte Metabolism III. Protein Metabolism IV. Growth Hormone Secretion V. Carbohydrate Metabolism VI. Fat Metabolism VII. Respiratory Effects VIII. The Influence of Synthetic Progestins on Electrolyte Metabolism IX. The Effect of Synthetic Progestins on Protein Metabolism ReferencesThe Thymus Gland: Experimental and Clinical Studies of its Role in the Development and Expression of Immune Function I. Introduction II. Historical III. Phylogenetic and Embryonic Development of the Thymus Gland IV. Modern Concepts of Thymus Function Derived from Experimental Studies V. Thymus Malfunction and Clinical Disorders VI. Summary ReferencesControl of Glucose Metabolism in the Human Fetus and Newborn Infant I. Introduction II. Modification of Maternal Metabolism by the Conceptus III. Placental Transport of Nutrients and Hormones IV. Fetal Glucose Metabolism V. The Newborn Infant: The Effects of Birth VI. Effects of an Abnormal Intrauterine Environment on Neonatal Glucose Homeostasis VII. Summary and Conclusions ReferencesHuman Adipose Tissue Dynamics and Regulation I. Introduction II. Sampling Techniques III. Morphology and Cell Composition IV. Human Adipose Tissue Metabolism V. Concluding Remarks ReferencesCoronary Disease and Carbohydrate and Fat Abnormalities I. Introduction II. Experimental Design III. Results IV. Discussion V. Summary ReferencesAuthor IndexSubject Index

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