Mims' Pathogenesis of Infectious Disease

Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery. - Microbial gene sequencing
- Up-to-date picture of the global burden of infectious diseases
- Role of bacterial virulence factors in vivo, as contrasted with possibilities based on in vitro evidence
- Latest data on combination vaccines, the promise of edible vaccines
- The spread of antibiotic resistance genes among bacteria
- HIV1 and HIV2; molecular biology, pathogenesis and origin
- Latest data on tuberculosis - the number one infectious disease worldwide
- Recent work on papillomaviruses, herpesviruses, BSE and variant CJD
- Latest data on microbial evasion of immune defences
- Origin and molecular biology of pandemic influenza
- Significance of toxins
- An update on vaccines, prions, immune evasion, microbial ligands and receptors

Tony Nash is Emeritus Professor of Infectious Diseases at the University of Edinburgh. He has had a distinguished career i the field of viral pathogenesis in which he has over a 150 publications. He is a Fellow of the Royal Society of Edinburgh and of the Academy of medical sciences of the UK.Cedric Mims began as a zoologist, studying under GP Wells and JBS Haldane at University College, London. He then went to the Middlesex Hospital Medical School, London, graduating in 1952. After hospital appointments he spent three years in Uganda studying tropical fevers, and then 16 years in Canberra, Australia, interspersed with two years in the USA. This was followed by a 20-year period in London as Professor of Microbiology at Guy's Hospital Medical School, where his enthusiasm for teaching found its outlet. His entire career has focused on infectious diseases and immunology, and he has produced five books and more than a hundred scientific papers on these subjects. He has four children and nine grandchildren and lives in the Sussex countryside.

1. General Principles2. Attachment to and Entry of Microorganisms into the Body3. Events Occurring Immediately After the Entry of the Microorganism4. The Encounter with the Phagocytic Cell and the Microbe's Answers5. The Spread of Microbes through the Body6. The Immune Response to Infection7. Microbial Strategies in Relation to the Immune Response8. Mechanisms of Cell and Tissue Damage9. Recovery from Infection10. Failure to Eliminate Microbe11. Host and Microbial Factors Influencing12. Vaccines and How they Work