Biological Activities of Steroids in Relation to Cancer

Biological Activities of Steroids in Relation to Cancer covers the proceedings of the conference sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, and the U. S. Department of Health, Education and Welfare. The text focuses on the influence of steroids on medical approaches to the cure of cancer, including steroid chemistry, estrogen metabolism, and mammary cancer. The selection first offers information on steroids growth and cancer, advances in steroid chemistry, and the physiology and pharmacology of steroids affecting tumor growth. Discussions focus on rapid development of mammary cancer, pituitary functions, androgens, estrogens, and progestins. The book also ponders on the binding of steroid hormones by plasma proteins; the effects of steroids on the levels of the plasma 17-hydroxycorticosteroids and the serum protein-bound iodine; and the metabolism of dehydroisoandrosterone. The text evaluates studies on estrogen metabolism, biochemical parameters of estrogen action, and enzymatic transport of hydrogen by estrogenic hormones. The manuscript also elaborates on the fate of steroid estrogens in target tissues, effect of steroids on calcium dynamics, and steroids and experimental mammary cancer. The selection is a valuable source of information for readers interested in the use of steroids in treating cancer.

ContentsContributors Preface I. Introduction 1. Steroids, Growth, and Cancer Discussion II. Steroid Structure and Function 2. Some Recent Advances in Steroid Chemistry Discussion 3. Physiology and Pharmacology of Steroids Affecting Tumor Growth Discussion III. Steroid Metabolism and Biochemistry 4. The Binding of Steroid Hormones by Plasma Proteins Discussion 5. The Effects of Steroids on the Levels of the Plasma 17-Hydroxycorticosteroids and the Serum Protein-Bound Iodine Discussion 6. The Metabolism of Dehydroisoandrosterone Discussion 7. Recent Studies on Estrogen Metabolism Discussion 8. Biochemical Parameters of Estrogen Action Discussion 9. Enzymatic Transport of Hydrogen by Estrogenic Hormones Discussion 10. Fate of Steroid Estrogens in Target Tissues Discussion 11. The Prostate As a Target Organ for Steroids Discussion 12. Effect of Steroids on Calcium Dynamics Discussion 13. The Effect of Estrogen Therapy on Incorporation of Formate-C14 into Human Breast Cancer in Vitro Discussion IV. Steroids and Experimental Tumors 14. Studies of Hormone Dependency Employing Interstitial Cell Testicular Tumors of Mice Discussion 15. Steroid-Responsive Neoplasms in Rats and Mice Discussion 16. Steroids and Experimental Mammary Cancer Discussion 17. Steroid Effects on Heterologously-Transplanted Human Tumors Discussion 18. Steroid-Induced Tumors in Animals Discussion V. Hormones and Human Cancer 19. Evaluation of Endocrine Ablative Surgery in the Treatment of Mammary Carcinoma: A Preliminary Study on Survival Discussion 20. Testosterone Propionate Therapy of Breast Cancer-A Report for the Cooperative Breast Cancer Group 21. Hormonal Therapy of Breast Cancer Discussion 22. Evaluation of 4-Androstene-3ß,l7ß-diol Diacetate in the Treatment of Advanced Breast Cancer 23. -1-Testololactone, Androsterone, and 5a-Androstane-3a,l7ß-diol Dipropionate in the Treatment of Advanced Breast Cancer 24. An Evaluation of 9a-Bromo-ll-ketoprogesterone in the Treatment of Metastatic Breast Carcinoma 25. Comparison of the Antitumor Effects of 17a-Methyl-19-Nortestosterone and Testosterone Propionate in Advanced Mammary Carcinoma 26. The Cooperative Study Program in Therapy of Advanced Prostatic Cancer Discussion 27. The Sex Hormones and Cortisone in the Treatment of Inoperable Bronchogenic Carcinoma Discussion 28. Clinical Observations on the Effect of Progesterone in the Treatment of Metastatic Endometrial Carcinoma Discussion 29. Steroid Metabolism in Endocrine Tumors Discussion 30. Regression of Adrenal Cancer and Suppression of Adrenal Function in Man by o,p'-DDD Discussion 31. Serum Proteins in Breast Carcinoma: Effects of Androgen Therapy 32. Cellular Prognostic Factors in Breast Cancer Hormone Therapy Discussion Glossary Author Index Subject Index