Applied Virology

Applied Virology covers the practical applications of the developments in basic virology, not only to virology but to other disciplines as well, and demonstrates the impact of virus diseases on the environment, economy, and the health of man, animals, and plants. The book discusses topics on new virus vaccine technology and chemotherapy; the status of vaccination against viral diseases; and the epidemiology and diagnosis of viral diseases. The text provides information on the strategy used to produce virus vaccines; on antiviral chemical compounds; on simple, rapid, and specific diagnostic techniques; and on epidemiology in relation to the prevention and control of virus diseases. Noninfectious, synthetized peptides used as safe virus vaccines are reviewed with special attention to their immunogenicity, multispecificity, and usefulness in case of epidemics. Virologists will find the book useful.

ContributorsPrefaceIntroductionI New Virus Vaccine Technology and Chemotherapy Chapter 1 Strategy for Virus Vaccine Development I. Introduction II. Choice of Viral Vaccines III. Live Virus Vaccines IV. Categories of Vaccines Containing Nonreplicating Antigens V. Conclusions References Chapter 2 Genetic Engineering Technology in Vaccine Production and Control of Animal Virus Diseases I. Introduction II. Genetic Engineering of Rabies Vaccine III. Genetic Engineering of Foot-and-Mouth Disease Vaccine IV. Priorities for Genetic Engineering of Other Animal Vaccines V. Technology Transfer to Developing Countries References Chapter 3 Location and Sequence of a Critical Antigenic Site on VP1 of Poliovirus Type 3 and Its Relevance to the Development of Novel Vaccines against Poliomyelitis I. Introduction II. Antigenic Analysis of Poliovirus Using Monoclonal Antibodies III. Location and Primary Structure of the Antigenic Site for Neutralization of Poliovirus Type IV. Discussion and Conclusion References Chapter 4 Synthesis of a Viral Membrane Protein in Bacillus Subtilis I. Introduction II. Construction of a Secretion Vector for Expression of Foreign Genes in Bacillus Subtilis III. Modification of the El Membrane Protein Gene of Semliki Forest Virus IV. Joining of the E1 Gene to the Secretion Vector V. Expression of E1 in Bacillus Subtilis VI. Conclusions References Chapter 5 Production of Hepatitis-Safe Plasma Proteins from Cold Sterilized Plasma I. Introduction II. Cold Sterilization of Plasma III. Combination of Cold Sterilization and Adsorption IV. Properties of Sterilized Factor IX Concentrate V. Properties of Stabilized Serum Biseko References Chapter 6 Factors Influencing the Performance of Foot-and-Mouth Vaccines under Field Conditions I. Introduction II. The Disease III. The Vaccine IV. The Host V. The Human Element VI. Graphic Models VII. Discussion References Chapter 7 Progress in Antiviral Chemotherapy I. Introduction II. Viral Vaccines III. Passive Immunization IV. Antiviral Agents V. Conclusions References Chapter 8 Acyclovir: A Review of the Preclinical and Clinical Status I. Introduction II. In Vitro Activity III. Mechanism of Action IV. Animal Studies V. Pharmacokinetics in Man VI. Clinical Experience VII. Tolerance in Clinical Use VIII. Conclusions ReferencesII Present Status of Vaccination Againts Viral Diseases Chapter 9 Worldwide and Differing Vaccinations against Human Viral Diseases I. Introduction II. Vaccine-Preventable Viral Diseases III. Individual Diseases IV. Measles Eradication V. Conclusion References Chapter 10 Principal Human Viral Diseases: Present Status of Vaccination I. Introduction II. Measles III. Poliomyelitis IV. Viral Hepatitis V. Rabies VI. Yellow Fever References Chapter 11 Present Status of Vaccination against Poliomyelitis in the African Region of the World Health Organization I. Introduction II. Epidemiology of Poliomyelitis III. Expanded Program of Immunization (EPI) IV. Principal EPI Achievements V. Conclusion References Chapter 12 Hepatitis B Virus: Approaches to Control and Vaccination I. Introduction II. Immunochemical Properties of Hepatitis B Surface Antigen III. Nature of the Hepatitis B Genome and Molecular Cloning Studies IV.

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