Cellular and Molecular Mechanisms of Inflammation

Cellular and Molecular Mechanisms of Inflammation: Signal Transduction in Inflammatory Cells, Part A is a collection of papers that discusses the mechanisms of the transduction of signals linking stimulated receptors and cellular function. This book describes the pathways of signal transduction involved in stimulating functions of inflammatory cells connected with host defense and development of inflammatory injury. One paper notes the potential of using fluorescence methodology in analyzing ligand-receptor interactions in living systems during the natural abundance of cell surface receptors. Another paper discusses the structure and function of GTP-binding proteins in neutrophil signal transduction, particularly the role of oligomeric G proteins in signal transduction. One concern in signal transduction research is the physiological significance of the presence of multiple forms of proteins that can have identical functions. One paper reviews phosphatidylcholine breakdown and hormone action in the rat liver, focusing on G proteins and on inositol phospholipid breakdown. This book also discusses calcium translocation in signal transduction, as well as, a novel signal transduction pathway involving phosphatidylinositol 3-kinase. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

Preface Chapter 1 Real-Time Analysis of Ligand-Receptor Dynamics and Binding Pocket Structure of the Formyl Peptide Receptor 1 Introduction Birth of Real-Time Assays for Neutrophil Receptor Dynamics Early Methods 1980-1985 Receptor-G Protein Interactions Intact Cell Amplification Ligand-Receptor Dynamics for Unlabeled Ligands Receptor Binding Pocket Topography Prospects for Generalizing Real-Time Methods for Kinetic and Structural Analyses References Chapter 2 Structure and Function of GTP-Binding Proteins in Neutrophil Signal Transduction Introduction Oligomeric G Proteins Neutrophil G Proteins Low-Molecular-Weight G Proteins LMWGs in Neutrophils G Protein Regulation of Oxidant Production in Neutrophils Summary and Conclusions References Chapter 3 Regulation of Phospholipase C Isozymes Activation of PLC by G Protein-Dependent and -Independent Pathways Heterogeneity in the PI Response to Specific Ligands Multiple Forms of PLC G Protein-Dependent Activation of PLC G Protein-Dependent Inhibition of PLC Activation of PLC by Growth Factor Receptor Tyrosine Kinases Activation of PLC--1 Through Tyrosine Phosphorylation by Nonreceptor PTK Prospective References Chapter 4 Phosphatidylcholine Metabolism in Signal Transduction Introduction Liver as an Experimental System Diacylglycerol Accumulation Phosphatidate Accumulation In Vivo Measurements of DAG and PA in the Regenerating Liver Role of DAG and PA in Liver Function Future Directions References Chapter 5 Calcium Translocation in Signal Transduction Introduction Ca2+ Signal; Studies in Cell Populations and Single Neutrophils Neutrophil Plasma Membrane: Ion Channels, Membrane Potential, and Ca2+ Influx Intracellular Ca2+ Stores in Myeloid Cells Phosphatidylinositol Turnover Role of [Ca2+]i in the Regulation of Neutrophil Functions Concluding Remarks References Chapter 6 Inositol Phosphate Metabolism Introduction to Phosphatidylinositol Turnover Discovering the Biological Role of Inositol Phosphates Interconversion of the Phosphatidylinositols Ptdlns 3-Kinase Production of Inositol Phosphates Ptdlns-Specific PLC Cyclic Inositol Phosphate Pathway Cyclic Hydrolase Ins(1,4,5)P3/Ins(1,3,4,5)P4 Pathway Possible Functions of Ins(1,3,4,5)P4 Ins(1,4,5)P3 3-Kinase Inositol Polyphosphate 5-Phosphatase Other Pathways of Inositol Phosphate Metabolism Inositol Polyphosphate 1-Phosphatase Inositol Polyphosphate 4-Phosphatase Inositol Polyphosphate 3-Phosphatase Phosphorylation of Ins(1,3,4)P3 Monophosphatase Closing Comments References Chapter 7 Phosphatidylinositol 3-Kinase: A Novel Signal Transduction Pathway? Introduction Pathway and Structures for the Conventional Polyphosphoinositides A Distinct Phosphatidylinositol Kinase Associates with Activated Protein Tyrosine Kinases Phosphatidylinositol 3-Kinase Is Linked to Cell Proliferation and Transformation Discovery of Other Novel Polyphosphoinositides Critical Determinants for Association of Phosphatidylinositol 3-Kinase and Protein Tyrosine Kinases Conclusions References Index

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