Clinical Immunobiology

Clinical Immunobiology, Volume 2 covers the advances in the field being made to apply bone marrow transplantation to the treatment of several diseases. This volume is divided into 11 chapters and begins with surveys of the clinical considerations of bone marrow transplantation. Considerable chapters are devoted to the application of this transplantation to the treatment of various diseases, including aplastic anemia, aregenerative pancytopenia, leukemia, uniformly fatal severe combined immunodeficiency diseases, and Wiskott-Aldrich syndrome. Other chapters examine the cellular engineering in the form of bone marrow and thymus transplantation. The remaining chapters consider the effects of exposure to excessive amounts of radiation or cytotoxic chemicals, as well as the hematopoietic failure based on malfunction of the complex process of normal hematological development and maintenance. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

List of ContributorsPrefaceContents of Volume 1Bone Marrow Transplantation I. Introduction II. Terminology III. Technique IV. Histocompatibility V. Preparation of the Recipient VI. Clinical Results VII. Special Consideration According to Underlying Disease VIII. Support for the Patient without Marrow Function IX. Success or Failure of Engraftment X. GVH Disease XI. Immunological Status of Long-Term Survivors of Marrow Transplantation XII. Infection following Engraftment XIII. Nature of Tolerance XIV. Antileukemic Effect (Adoptive Immunotherapy) XV. Malignant Transformation of Donor Cells XVI. A Look at the Future ReferencesBone Marrow Transplantation for Aplasias and Leukemias I. The First Bone Marrow Grafts in Man after Irradiation Exposure II. Experimental and Clinical Bone Marrow Graft in Leukemia after Irradiation Conditioning (GVH versus GVL) III. Bone Marrow Graft in Aplasias and Leukemias after ALG Conditioning; Split Lymphocyte Chimerism IV. Bone Marrow Transplantation Using a Combination of ALG and Cyclophosphamide V. Experimental Research for New Means to Control GVH ReferencesBone Marrow and Thymus Transplants: Cellular Engineering to Correct Primary Immunodeficiency I. Lymphoid System Development and the Concept of Two Interacting Immunity Systems II. Correction of the DiGeorge Syndrome by Thymus Transplantation III. Bone Marrow Transplants to Correct Immunodeficiency Diseases IV. Bone Marrow Transplant to Correct SCID V. Bone Marrow Transplant in Treating the Wiskott-Aldrich (WA) Syndrome VI. Aspiration as a Problem in SCID Patients Fully Reconstituted Immunologically by Bone Marrow Transplantation VII. Efforts to Use Isolated Stem Cells from Immunological Reconstitution in SCID VIII. Efforts to Use Bone Marrow Transplantation to Correct SCID When a Matched Sibling Donor Is Not Available IX. Genetic Determination of Histocompatibility Characteristics in Men and Mice X. Bone Marrow Transplantation to Correct SCID with a Donor Mismatched with Recipient at All HL-A SD Determinants but Matched at the LD Locus Controlling MLC XI. Correction of Clq Deficiency by Marrow Transplantation in SCID XII. Relationship of Successful Marrow Transplantation in Aregenerative Anemia and Leukemia to Transplantations used in SCID XI. Correction of Clq Deficiency by Marrow Transplantation in SCID XIII. Correction of SCID by Fetal Liver Transplantation XIV. New Experimental Observations Relevant to Cellular Engineering in Man XV. Cellular Engineering and Common Diseases of Man XVI. Cellular Engineering and Immunodeficiencies Based on Defective Development of Biological Amplification Systems XVII. Immunodeficiencies in Common Human Diseases-A Challenge for Cellular Engineering XVIII. Nutritional Deprivation and Immunological Deficiency-A Possible Challenge for Cellular or Molecular Engineering XIX. Aging and Cellular Engineering BibliographySelective Immunotherapy with Transfer Factor I. Introduction II. Early Beginnings-Viable Cells as Vehicles of TF III. Histoincompatible Cell Transfer and Graft-versus-Host (GvH) Disease IV. Viable Lymphocytes versus TFD for Immunotherapy V. Later Developments-Availability of TFD VI. The Scope of TFD for Immunological Reconstitution VII. TFD Immunotherapy of Infectious Disease VIII. Reconstitution of Congenital Immunodeficiency Diseases with TFD Therapy IX. TFD and Cancer Immunotherapy X. Immunotherapy with TFD-Unresolved Questions XI. Conclusion ReferencesTransfer Factor I. Introduction II. Preparation of Transfer Factor III. Evaluation of Cellular Immunity IV. Technique of Transfer Factor Therapy and Prophylaxis of Infection V. Wiskott-Aldrich Syndrome VI. Mucocutaneous Candidiasis VII. Combined Immunodeficiency Disease VIII.