Clinical Immunobiology

Clinical Immunobiology, Volume 4 is a 13-chapter text that covers the advances in understanding of the concepts and practical applications of lymphoid subpopulations and the major histocompatibility complex (MHC). The first chapter presents an overview of the problems of various subpopulations of cells involved in the immune system. The succeeding chapters describe the techniques used for cell classification, either by their cell surface phenotype or by their responsiveness to a series of different stimuli. These chapters include surveys of the methods of detection of complement receptors and expression of these receptors on the surface of both normal and leukemic human lymphocytes. A discussion of the evidence that different T-lymphocyte populations differentially express receptor for IgG and IgM is also provided. Other chapters describe the relationship of MHC to serology of cell surface antigens and reactivity in the mixed leukocyte culture test. This work also explores the methods that employ the so-called "proliferative and cytotoxic responses". The remaining chapters look into the association between HLA antigens and a variety of different diseases. These chapters also discuss other genetic markers in the HLA linkage group. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

List of ContributorsPrefaceContents of Previous VolumesGeneral Orientation of Human Lymphocyte Subpopulations I. Introduction II. Cytoplasmic Immunoglobulin III. Membrane Immunoglobulin IV. la System V. Epstein-Barr Virus (EBV) Receptor VI. Complement Receptors VII. Receptors for Fc Region of Immunoglobulins VIII. Enzymatic Markers IX. Receptors for Peanut Agglutinin X. Erythrocyte Receptors XI. Surface Antigens of Lymphocyte Subpopulations Defined by Monoclonal Antibodies XII. Relationship between T- Cells and Monocytes XIII. Distinction of Lymphocytes from Monocytes XIV. The Third-Cell Population or Unclassified Lymphoid Cells XV. Summary ReferencesLymphocyte Membrane Complement Receptors I. Introduction II. Methods for Detection of C Receptors III. Expression of C Receptors and Other Surface Markers on Normal and Leukemic Human Lymphocytes IV. Interpetation and Significance ReferencesRegulatory Human T-Cell Subpopulations Defined by Receptors for IgG or IgM I. Introduction II. Enumeration and Isolation of T.M and T.G Cells III. Morphology of T.M and T.G Cells IV. Tissue Distribution of T.M and T.G Cells V. Functional Analysis of T.M and T.G Cells VI. Clinical Relevance of T.M and T.G Subpopulations Selected Reading AddendumMitogens I. Introduction II. Fundamentals of Lectin-Induced Mitogenesis III. Procedure for Determining in Vitro Lectin-Induced Activation of Lymphocytes IV. Clinical Usefulness of Lectins General Reading ReferencesNatural Killer Cells and Cells Mediating Antibody-Dependent Cytotoxicity Against Tumors I. Introduction II. Methods III. Characteristics of NK Cells and Their Relationship to K Cells IV. Specificity of Natural Cytotoxicity V. Factors Affecting Levels of NK and K Cell Activities VI. Possible Clinical Significance of These Effector Cells ReferencesRegulation of the Immune System by Lymphocyte Sets: Analysis in Animal Models I. General Considerations II. Analysis in the Mouse III. Conclusions Selected ReferencesThe Serology of HLA-A, -B, and -C I. Introduction II. Experimental Methods and Findings III. Conclusions ReferencesThe Serology of HLA-DR I. Introduction II. Technical Considerations III. Results IV. Discussion ReferencesCellular Immunogenetics-Definition of HLA-D Region Encoded Antigens by T Lymphocyte Reactivities I. Introduction II. Mixed Leukocyte Culture Homozygous Typing Cells III. Primed LD-Typing (PLT) IV. General Discussion ReferencesCell-Mediated Lympholysis I. Introduction II. Terminology III. Technique IV. Specificity of Cell-Mediated Lympholysis V. Genetic Control of CML VI. Cell-Mediated Lympholysis Typing VII. Preliminary Information from CML Typing Experiments VIII. Future Prospects Suggested Reading ListHLA and Graft Survival I. Introduction II. Methodology III. Results IV. Discussion ReferencesHLA and Disease I. Introduction II. Methods III. Relationships Between HLA and Diseases IV. Disease Heterogeneity V. Inheritance of Disease Susceptibility and Resistance VI. Mechanisms that Can Explain the Associations VII. Diagnostic and Prognostic Value Key ReferencesOther Markers in the HLA Linkage Group I. Introduction II. Genetic Considerations III. Other Markers in the HLA Linkage Group IV. Complement Components V. Intracellular Enzymes VI. Concluding Remarks Selected ReferencesIndex

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