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Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future.
Woolley, David; Woolley, Adam
Introduction to Toxicology: The Necessity of Measurement. Normality: Definition and Maintenance. Determination of Toxicity: The Basic Principles. Determination of Toxicity: In Vitro and In Silico. Safety Pharmacology. Determination: General and Reproductive Toxicology. Distinguishing a Toxicological Effect from an Expected Pharmacological One. Determination: Genotoxicity and Carcinogenicity. Determination: Dermal Toxicity-Sensitization, Irritation, and Corrosion. Determination of Immunotoxicity: Biologics and Beyond. Determination of Nanotoxicity. Determination: Environmental Toxicology and Ecotoxicology. Interpretation: Basic Principles. Interpretation: Different Data Types. Prediction of Hazard. Background to Risk Due to Toxicity. Risk Assessment in Practice and Setting Exposure Limits. Risk Assessment for Extractables, Leachables, and Impurities. Risk Assessment and Management in the Workplace. Risk Assessment: Carcinogenicity; The Environment, Evolution, and Overview of Risk Assessment. Evaluation of Specific Classes of Chemical. Errors in Toxicology: An Introduction to the 4Ms. The Future of Toxicity Testing and Risk Assessment.
